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1 | TITLE: Simvastatin in the treatment of hypercholesterolaemia in patients with essential hypertension.ABSTRACT: Mortality from coronary artery disease is a common problem in treated hypertensive patients, and these people have a high prevalence of elevated cholesterol levels. A study was undertaken to determine whether ... |
1 | TITLE: Blood coagulation findings and the efficacy of factor XIII concentrate in premature infants with intracranial hemorrhages.ABSTRACT: Coagulation findings were examined in 55 cases of neonatal intracranial hemorrhages (ICH). Marked decreases of the platelet count, fibrinogen, factor XIII (F XIII) activity, were ob... |
1 | TITLE: A clinical comparison of central and peripheral argon laser panretinal photocoagulation for proliferative diabetic retinopathy.ABSTRACT: Fifty eyes with three or four diabetic retinopathy risk factors received argon laser panretinal photocoagulation (PRP) with treatment randomly assigned to either central or per... |
1 | TITLE: Thrombosis prophylaxis with low molecular weight heparin in total hip replacement.ABSTRACT: In a randomized prospective trial, the efficacy of low molecular weight heparin (LMWH) (Fragmin) and dextran 70 (Macrodex) in preventing deep vein thrombosis (DVT) in the legs was evaluated in 98 consecutive patients unde... |
1 | TITLE: Response of thromboxane B2, malondialdehyde and platelet sensitivity to 3 weeks low-dose aspirin (ASA) in healthy volunteers.ABSTRACT: To examine the effects of low-dose aspirin thromboxane B2 (TXB2), malondialdehyde (MDA) and platelet sensitivity to prostaglandin I2 (PGI2) have been measured in a total of 18 he... |
1 | TITLE: Metabolic effects of biosynthetic human proinsulin in type 2 diabetes mellitus.ABSTRACT: Due to a longer plasma half-life and half-time of action on glucose metabolism biosynthetic human proinsulin was thought to be an alternative to long-acting insulin preparations. To test this hypothesis we studied 23 type 2 ... |
1 | TITLE: Comparison of continuous and intermittent bolus infusions of metoclopramide during 5-day continuous intravenous infusion with cisplatin.ABSTRACT: In order to decide the administration method of metoclopramide for prevention or control of chemotherapy-induced nausea and vomiting in multidrug chemotherapy, with ci... |
1 | TITLE: Influence of beta-blockade on circulating plasma levels of 3-methoxy-4-hydroxy phenylethylene glycol (MHPG) during exercise in moderate hypertension.ABSTRACT: 1. The effect of exercise testing and beta-blockade on plasma norepinephrine (PNE), and secretion of its metabolite 3-methoxy-4-hydroxyphenylethylene glyc... |
1 | TITLE: Chronic Chlamydia pneumoniae infection as a risk factor for coronary heart disease in the Helsinki Heart Study.ABSTRACT: To investigate in the prospective Helsinki Heart Study, whether chronic Chlamydia pneumoniae infection, indicated by elevated antibody titers against the pathogen, chlamydial lipopolysaccharid... |
0 | TITLE: The predictive value of silent ischemia at an exercise test before discharge after an episode of unstable coronary artery disease. RISC Study Group.ABSTRACT: The prognostic value of silent ischemia during a symptom-limited predischarge exercise test (ET) was evaluated in 740 men after an episode of unstable angi... |
1 | TITLE: Efficacy of orally administered ondansetron in the prevention of postoperative nausea and vomiting: a dose ranging study.ABSTRACT: In a placebo-controlled, double-blind study, we have compared the efficacy of ondansetron 16 mg, 8 mg and 1 mg administered 8-hourly for prevention of postoperative nausea and vomiti... |
1 | TITLE: Impact of converting enzyme inhibition on progression of chronic heart failure: results of the Munich Mild Heart Failure Trial.ABSTRACT: Neurohormonal activation has major impact on the pathophysiology of congestive heart failure. The Munich Mild Heart Failure Trial was designed to test the hypothesis that inter... |
1 | TITLE: Paroxetine in the treatment of elderly depressed patients in general practice: a double-blind comparison with amitriptyline.ABSTRACT: A total of 101 patients entered a double-blind, parallel-group study in general practice, comparing the efficacy and tolerability of paroxetine and amitriptyline in elderly depres... |
1 | TITLE: Sodium fluoride prevents bone loss in primary biliary cirrhosis.ABSTRACT: Low-bone-turnover osteoporosis is a common complication of primary biliary cirrhosis (PBC). Since sodium fluoride stimulates bone formation we assessed the effect of this drug on bone mass in a 2-year, prospective, double-blind trial inclu... |
1 | TITLE: Growth hormone stimulates galactopoiesis in healthy lactating women.ABSTRACT: Sixteen normally lactating women underwent a double-blind randomized placebo-controlled trial of recombinant human growth hormone (hGH) to assess the effect of hGH on milk production in early lactation. Milk volumes were measured by te... |
1 | TITLE: Thrombolysis with recombinant human tissue-type plasminogen activator during instability in coronary artery disease: effect on myocardial ischemia and need for coronary revascularization. TRIC Study Group.ABSTRACT: Two hundred five men, 40 to 70 years of age, admitted to the coronary care unit with unstable coro... |
1 | TITLE: Epidural lidocaine with sufentanil and epinephrine for abdominal hysterectomy under general anaesthesia: respiratory depression and postoperative analgesia.ABSTRACT: The purpose of this investigation was to compare the analgesic actions and side-effects of a 50 micrograms epidural bolus of sufentanil and 50 micr... |
0 | TITLE: Prevention of lower extremity venous thrombosis by early mobilization. Confirmation in patients with acute myocardial infarction by 125I-fibrinogen uptake and venography.ABSTRACT: To determine the effects of early ambulation on peripheral venous thrombosis in the coronary care unit, 29 patients with acute myocar... |
1 | TITLE: Effects of coronary artery bypass grafting on resting and exercise hemodynamics in patients with stable angina pectoris: a prospective, randomized study.ABSTRACT: In this prospective randomized study, resting and exercise hemodynamics were determined in the nonmedicated state before ("entry") and 1 year after co... |
1 | TITLE: Procainamide conversion of acute atrial fibrillation after open-heart surgery compared with digoxin treatment.ABSTRACT: In 30 patients who developed atrial fibrillation after open-heart surgery the efficacy of intravenous procainamide was evaluated and compared with standard acute digoxin digitalisation. The pat... |
1 | TITLE: Randomised comparison of olsalazine and mesalazine in prevention of relapses in ulcerative colitis.ABSTRACT: Sulphasalazine extends remissions and lessens disease activity during relapses of ulcerative colitis, but it also causes many adverse side-effects. The adverse reactions are mostly attributable to the sul... |
1 | TITLE: Determinants of the need for early acute intervention in patients treated conservatively after thrombolytic therapy for acute myocardial infarction. TAMI-5 Study Group.ABSTRACT: This study sought to determine whether clinical variables can be used to identify patients at high risk of recurrent spontaneous myocar... |
1 | TITLE: Late streptokinase infusion and antithrombotic treatment in myocardial infarction reduce subsequent myocardial ischemia.ABSTRACT: Of 255 consecutive patients with acute myocardial infarction, 111 were eligible for attempted late thrombolysis. They were randomly assigned to either thrombolytic and antithrombotic ... |
1 | TITLE: Thiazide for the postponement of postmenopausal bone loss.ABSTRACT: The effect of thiazide on bone mineral loss in normal postmenopausal women was examined during a 3 yr placebo-controlled clinical trial. Sixty-three healthy women in their early menopause were randomized to treatment with bendroflumethiazide 5 m... |
1 | TITLE: Cotrimoxazole prophylaxis in patients with leukemia and prolonged granulocytopenia.ABSTRACT: Sixty-three patients with acute nonlymphoid leukemia (ANLL) under cytostatic treatment were investigated in a randomized trial to determine whether oral administration of cotrimoxazole (TMP/STX) would reduce the rate of ... |
1 | TITLE: Are bile bacteria relevant to septic complications following biliary surgery?ABSTRACT: Bile bacteriology, wound sepsis and the effect of prophylactic antibiotics have been studied in a controlled prospective double blind randomized trial on 375 patients undergoing elective cholecystectomy at a district general h... |
0 | TITLE: Effect of postoperative total parenteral nutrition (TPN) as an adjunct to gastrectomy for advanced gastric carcinoma.ABSTRACT: Clinical staging and immune reactivity were correlated in 39 patients who underwent gastrectomy for primary gastric cancer. Cellular immunity was depressed as the stage of cancer advance... |
1 | TITLE: Larvicidal activity of albendazole against Necator americanus in human volunteers.ABSTRACT: This study evaluated the efficacy and tolerance of a single oral 400-mg dose of albendazole on Necator americanus larvae, and compared its efficacy when administered between meals or with a meal. Twenty-nine healthy and h... |
1 | TITLE: Effects of two energy: nitrogen ratios in patients with gastroenterological disease and malnutrition.ABSTRACT: In 10 patients with active gastroenterological disease and protein-malnutrition (weight: 77.3 +/- 2.6 (mean +/- SEM) percent of ideal body weight, serum-albumin levels: 2.59 +/- 0.17 mg/100 ml) a random... |
1 | TITLE: Effects of the estrogenicity of levonorgestrel/ethinylestradiol combinations of the lipoprotein status.ABSTRACT: Ninety-eight women seeking contraceptive advice were randomly allocated to 6 months of treatment with one of the following four combinations of ethinylestradiol (EE) and levonorgestrel (NG): 20/250, 3... |
1 | TITLE: Effects of dexfenfluramine on free fatty acid turnover and oxidation in obese patients with type 2 diabetes mellitus.ABSTRACT: To test the potential effects of dexfenfluramine (dF) on enhancing free fatty acid (FFA) turnover and oxidation rates, 11 obese female non-insulin-dependent diabetes mellitus (NIDDM) out... |
1 | TITLE: Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy. Metoprolol in Dilated Cardiomyopathy (MDC) Trial Study Group.ABSTRACT: Several small studies have suggested beneficial effects of long-term beta-blocker treatment in idiopathic dilated cardiomyopathy. Our large multicentre study aimed to find... |
1 | TITLE: Vitamin A supplementation and childhood malaria in northern Ghana.ABSTRACT: Two companion, randomized, placebo-controlled trials of prophylactic vitamin A supplementation provided the opportunity to assess the impact of supplementation on malaria parasitemia, morbidity, and mortality in young children in norther... |
1 | TITLE: Correcting respiratory rate for the presence of fever.ABSTRACT: This study defines what degree of respiratory rate (RR) elevation can be attributed to fever using a double blind randomized pre- and post-acetaminophen comparison of vital signs of febrile children presenting to an outpatient clinic. Inclusion crit... |
0 | TITLE: The effect of raw potato starch on energy expenditure and substrate oxidation.ABSTRACT: Because resistant starch (RS) is not absorbed as glucose in the small intestine of healthy humans, postprandial thermogenesis should be lower after the intake of RS as compared with digestible starch. To evaluate this hypothe... |
1 | TITLE: One-year acarbose treatment raises fasting serum acetate in diabetic patients.ABSTRACT: alpha-Glucosidase inhibitors such as acarbose improve blood glucose control in diabetes by delaying or reducing carbohydrate absorption. The fermentation of malabsorbed carbohydrate in the colon is associated with the product... |
1 | TITLE: Characteristics and consequences of myocardial infarction after percutaneous coronary intervention: insights from the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT).ABSTRACT: We examined the results of the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT) to determine the chara... |
1 | TITLE: Impact of surgical stress on the haemodynamic profile of isoflurane-induced hypotension.ABSTRACT: It has been suggested that stimulation of adrenoreceptors could be responsible for some of the haemodynamic effects of isoflurane. But there are no solid data demonstrating the role of sympatho-adrenal stimulation i... |
0 | TITLE: Prognostic value of serum lactic dehydrogenase (S-LDH) in multiple myeloma.ABSTRACT: Serum lactic dehydrogenase (S-LDH) was analysed at diagnosis in ninety-three patients with multiple myeloma. The patients were then followed up after a mean observation period of 39 months (SD 29). Serum lactic dehydrogenase was... |
1 | TITLE: The effect of cholinergic blockade on the ACTH, beta-endorphin and cortisol responses to insulin-induced hypoglycaemia.ABSTRACT: To assess the effect of cholinergic blockade on the ACTH, beta-endorphin and cortisol responses to insulin-induced hypoglycaemia, six healthy male volunteers each underwent two insulin... |
1 | TITLE: Metoprolol in acute myocardial infarction reduces ventricular arrhythmias both in the early stage and after the acute event.ABSTRACT: Fifty three of the 5778 patients included in the MIAMI (Metoprolol in Acute Myocardial Infarction) trial were investigated with long-term ECG recordings in order to evaluate the e... |
1 | TITLE: Enalapril maleate versus captopril. A comparison of the hormonal and antihypertensive effects.ABSTRACT: 24 hypertensive patients were randomised into 2 groups to compare the antihypertensive effects of enalapril and captopril over a 10-week period. In the hydrochlorothiazide run-in period, blood pressure was red... |
1 | TITLE: Efficacy of indobufen in the treatment of intermittent claudication.ABSTRACT: The aim of this trial was to assess the activity of indobufen compared with placebo in peripheral occlusive arterial disease of the lower limbs of atherosclerotic or diabetic origin. Fifty-two outpatients were admitted to the randomize... |
1 | TITLE: A randomized trial comparing cyclosporine with antilymphoblast-globulin-azathioprine for renal allograft recipients. Results at 2 1/2-6 years.ABSTRACT: Between September 1980 and June 1984, 246 splenectomized, transfused renal allograft recipients were stratified according to presence of diabetes and donor sourc... |
1 | TITLE: A randomized double-blind comparison of diltiazem and nifedipine in stable angina.ABSTRACT: A double-blind crossover trial comparing diltiazem (360 mg/day) and nifedipine (120 mg/day) for treatment of stable angina was conducted in 21 of 27 patients with proven coronary artery disease who completed the trial. Al... |
1 | TITLE: Acute coronary artery obstruction in myocardial infarction: overview of thrombolytic therapy.ABSTRACT: Pump failure, ranging from ventricular dysfunction to acute cardiogenic shock, is now the leading cause of cardiac death. Efforts at temporary mechanical or pharmacologic support of the heart have been largely ... |
1 | TITLE: Effect of an inhaled neutral endopeptidase inhibitor, thiorphan, on airway responsiveness to leukotriene D4 in normal and asthmatic subjects.ABSTRACT: Cysteinyl leukotrienes are potent inflammatory mediators that are considered to play a role in the pathophysiology of asthma. It can be postulated that leukotrien... |
1 | TITLE: Active compression-decompression resuscitation: effect on resuscitation success after in-hospital cardiac arrest.ABSTRACT: The purpose of this study was to test the hypothesis that active compression-decompression would improve resuscitation success in human subjects after cardiac arrest.Active compression-decom... |
1 | TITLE: Perioperative chemotherapy in patients with oral cancer.ABSTRACT: In the final report of a prospective, randomized controlled clinical trial, we report the results of using adjuvant perioperative chemotherapy in patients with oral cancer. Our study is based on the hypothesis of Goldie and Coldman. A total of 135... |
1 | TITLE: Laparoscopic salpingostomy versus laparoscopic local methotrexate injection in the management of unruptured ectopic gestation.ABSTRACT: Our goal was to determine whether laparoscopic salpingostomy is preferable to laparoscopic methotrexate injection in the management of unruptured tubal gestation.Forty-eight pat... |
1 | TITLE: Hypophosphataemia after renal transplantation: relationship to immunosuppressive drug therapy and effects on muscle detected by 31P nuclear magnetic resonance spectroscopy.ABSTRACT: Plasma phosphate values were examined in 72 renal transplant patients in a randomised trial of immunosuppression with azathioprine ... |
0 | TITLE: Lack of effects of angiotensin-converting enzyme (ACE)-inhibitors on glucose metabolism in type 1 diabetes.ABSTRACT: To evaluate the impact of ACE-inhibitors on insulin-mediated glucose uptake, glucose-induced glucose uptake, and hepatic glucose production, a sequential glucose clamp was performed in eight normo... |
1 | TITLE: The long-term effects of nedocromil sodium and beclomethasone dipropionate on bronchial responsiveness to methacholine in nonatopic asthmatic subjects.ABSTRACT: We investigated the effects of long-term treatment with two anti-inflammatory drugs, nedocromil sodium and beclomethasone dipropionate, on airway hyperr... |
1 | TITLE: Evaluation of the clinical pharmacology of nilvadipine in patients with mild to moderate essential hypertension.ABSTRACT: Eighty-four patients with diastolic blood pressure ranging from 100-115 mm Hg were randomized into a multicenter, parallel, double-blind, placebo-controlled, dose response study with nilvadip... |
1 | TITLE: Saccharomyces boulardii prevents diarrhea in critically ill tube-fed patients. A multicenter, randomized, double-blind placebo-controlled trial.ABSTRACT: To assess the preventive effect of Saccharomyces boulardii on diarrhea in critically ill tube-fed patients and to evaluate risk factors for diarrhea.Prospectiv... |
1 | TITLE: Comparison of a lifestyle modification program with propranolol use in the management of diastolic hypertension.ABSTRACT: To compare the management of mild diastolic hypertension (90 to 104 mm Hg) using a nonpharmacologic intervention with that using propranolol or placebo.Randomized, placebo-controlled trial wi... |
1 | TITLE: Preventing fungal infection in neutropenic patients with acute leukemia: fluconazole compared with oral amphotericin B.ABSTRACT: To compare the efficacy and tolerability of fluconazole and oral amphotericin B in preventing fungal infection in neutropenic patients with acute leukemia.A randomized, controlled, mul... |
1 | TITLE: Cow's milk versus soy-based formula in mild and moderate diarrhea: a randomized, controlled trial.ABSTRACT: We determined the efficacy of a soy-based formula compared with a cow's milk formula in infant refeeding after acute diarrhea in a randomized controlled double-blind clinical trial. Infants 2-12 months of ... |
1 | TITLE: Hemodynamic effects of morphine and nalbuphine in acute myocardial infarction.ABSTRACT: Hemodynamic effects of morphine and the new narcotic analgesic, nalbuphine, were compared in a randomized, double-blind study in 15 patients with acute myocardial infarction (11 men and four women, average age 56.2 yr) and no... |
1 | TITLE: Perioperative nutritional support in patients undergoing hepatectomy for hepatocellular carcinoma.ABSTRACT: This prospective, randomized, controlled trial from the University of Hong Kong evaluated the efficacy of perioperative parenteral nutrition (PN) in patients requiring hepatectomy for primary hepatocellula... |
1 | TITLE: Obese patients with type 2 diabetes poorly controlled by insulin and metformin: effects of adjunctive dexfenfluramine therapy on glycaemic control.ABSTRACT: Dexfenfluramine is well known for its weight reducing action and has been reported to improve glycaemic control in obese Type 2 diabetic patients not adequa... |
1 | TITLE: Treatment of Candida-infected denture stomatitis with a miconazole lacquer.ABSTRACT: The efficacy of a topically administered miconazole denture lacquer was compared with that of a placebo lacquer in the treatment of Candida-infected denture stomatitis. The study was a double-blind, randomized, controlled clinic... |
1 | TITLE: Jogging or walking--comparison of health effects.ABSTRACT: The present study compared the different health effects of 6 months' endurance training at two exercise intensities. Seventy-five nonsmoking, sedentary men were randomly assigned to either a home-based, unsupervised exercise program of 4 x 30 min/wk jogg... |
1 | TITLE: Inhibition of 5-hydroxytryptamine re-uptake impairs human gall-bladder emptying.ABSTRACT: 5-Hydroxytryptamine (5-HT) is an important neurotransmitter in the enteric nervous system. The intrinsic neural plexus of the gall-bladder resembles the enteric nervous system and similarly contains 5-HT neurones. The actio... |
1 | TITLE: The effects of single oral doses of 17 beta-oestradiol and progesterone on finger skin circulation in healthy women and in women with primary Raynaud's phenomenon.ABSTRACT: The effects of sex, the menstrual cycle, oral contraceptives, pregnancy, and the menopause on skin perfusion in healthy women and in patient... |
0 | TITLE: Effects of oral ranitidine, famotidine and omeprazole on gastric volume and pH at induction and recovery from general anaesthesia.ABSTRACT: We have studied, in 150 patients undergoing elective general surgery, the effect on gastric content of omeprazole 40 mg, ranitidine 300 mg and famotidine 40 mg, given orally... |
1 | TITLE: Withdrawal of digoxin from patients with chronic heart failure treated with angiotensin-converting-enzyme inhibitors. RADIANCE Study.ABSTRACT: Although digoxin is effective in the treatment of patients with chronic heart failure who are receiving diuretic agents, it is not clear whether the drug has a role when ... |
1 | TITLE: Effectiveness of a nicotine patch in helping people stop smoking: results of a randomised trial in general practice. Imperial Cancer Research Fund General Practice Research Group.ABSTRACT: To assess the effectiveness of 12 weeks' treatment with a 24 hour transdermal nicotine patch in helping heavy smokers to sto... |
0 | TITLE: Five years of physical exercise and low fat diet: effects on progression of coronary artery disease.ABSTRACT: This study was designed to assess the long-term effects of low-fat diet and intensive physical exercise.Long-term efficacy of exercise and diet was assessed in 18 nonselected, fully employed patients wit... |
1 | TITLE: Increase of birth weight following chloroquine chemoprophylaxis during the first pregnancy: results of a randomized trial in Cameroon.ABSTRACT: A randomized trial was carried out from 1991 to 1993 among women attending an antenatal clinic in Ebolowa, Cameroon where malaria is hyperendemic and transmission occurs... |
1 | TITLE: A controlled trial of verapamil in patients after acute myocardial infarction: results of the calcium antagonist reinfarction Italian study (CRIS)ABSTRACT: A multicenter, double-blind, randomized, placebo-controlled trial was conducted to assess the effects of verapamil on total mortality, cardiac mortality, rei... |
1 | TITLE: Single- versus multiple-dose mezlocillin prophylaxis in emergency cesarean section.ABSTRACT: 163 patients undergoing emergency cesarean section were prospectively and randomized evaluated to determine the effect of mezlocillin in reducing postoperative morbidity. We compared a single 5-gram preoperative dose and... |
1 | TITLE: Intravenous propafenone for termination of reentrant supraventricular tachycardia. A placebo-controlled, randomized, double-blind, crossover study.ABSTRACT: To assess the antiarrhythmic efficacy of intravenous propafenone, 20 patients with inducible sustained supraventricular tachycardia received propafenone, 2 ... |
1 | TITLE: Comparison of spectinomycin hydrochloride and aqueous procaine penicillin G in the treatment of uncomplicated gonorrhea.ABSTRACT: Men and women with uncomplicated gonorrhea were randomly assigned to receive aqueous procaine penicillin G (2,400,000 U for men; 2,400,000 U daily for 2 days for women) or spectinomyc... |
1 | TITLE: Angiotensin converting enzyme during acute and chronic enalapril therapy in essential hypertension.ABSTRACT: The acute and chronic effects of enalapril (MK421) were assessed in a double-blind randomized trial in subjects with essential hypertension. In acute studies, twelve subjects received enalapril (10 mg p.o... |
1 | TITLE: Desflurane analgesia for vaginal delivery.ABSTRACT: The use of subanaesthetic concentration of inhalational anaesthetic for vaginal delivery offers many advantages to the mother and newborn. Desflurane, with the characteristics of rapid onset and minimal metabolism, may provide better analgesia and safety for la... |
0 | TITLE: Human immunodeficiency virus type 1 quantitative cell microculture as a measure of antiviral efficacy in a multicenter clinical trial.ABSTRACT: A quantitative cell microculture assay (QMC) was used to measure the human immunodeficiency virus type 1 (HIV-1) peripheral blood mononuclear cell (PBMC)-associated tite... |
1 | TITLE: Inhibition of steroid 5 alpha-reductase with finasteride: sleep-related erections, potency, and libido in healthy men.ABSTRACT: To objectively measure the effects of a 5 alpha-reductase inhibitor on erectile function, we studied 20 sexually active men (aged 41-64 yr) during double blind, randomized administratio... |
1 | TITLE: Endothelin-1 in pulmonary hypertension associated with high-altitude exposure.ABSTRACT: Endothelin-1 is involved in chronic pulmonary hypertension. Its role in acute pulmonary hypertension due to hypoxia in humans is not clear. We therefore studied the influence of hypoxia caused by exposure to high altitude on ... |
1 | TITLE: Indomethacin but not metoprolol reduces exercise-induced albumin excretion rate in type 1 diabetic patients with microalbuminuria.ABSTRACT: The effects of a single oral dose of indomethacin (1 mg kg-1) metoprolol (1.5 mg kg-1) and placebo on exercise-induced albumin excretion rate (AER) were compared in a random... |
1 | TITLE: Efficacy of lenograstim on hematologic tolerance to MAID chemotherapy in patients with advanced soft tissue sarcoma and consequences on treatment dose-intensity.ABSTRACT: This two-arm, double-blind, randomized trial was conducted to determine the effects of lenograstim, a glycosylated recombinant human granulocy... |
0 | TITLE: Open-label study to assess the efficacy, safety, and tolerability of fluvastatin versus bezafibrate for hypercholesterolemia.ABSTRACT: Increased levels of total cholesterol and low density lipoprotein cholesterol (LDL-C) are associated with the development of coronary artery disease, which has become a worldwide... |
1 | TITLE: Hemodynamic responses to intravascular injection of epinephrine-containing epidural test doses in adults during general anesthesia.ABSTRACT: Epidural anesthesia is sometimes initiated during general anesthesia, yet few data exist concerning efficacy of epinephrine-containing test doses.Thirty-six patients were r... |
1 | TITLE: Effects of nedocromil sodium in steroid-resistant asthma: a randomized controlled trial.ABSTRACT: Some patients with asthma respond poorly to corticosteroids and have persistent airway inflammation and daily clinical symptoms. The aim of this study was to investigate the effects of nedocromil sodium (NS), a nons... |
1 | TITLE: Improvement of exercise capacity with treatment of Cheyne-Stokes respiration in patients with congestive heart failure.ABSTRACT: The aim of this study was to determine the impact of nasal nocturnal oxygen therapy on respiration, sleep, exercise capacity, cognitive function and daytime symptoms in patients with c... |
0 | TITLE: Risks for sensorimotor peripheral neuropathy and autonomic neuropathy in non-insulin-dependent diabetes mellitus (NIDDM).ABSTRACT: Identification of risk factors for development of diabetic sensorimotor peripheral neuropathy (DSPN) and diabetic autonomic neuropathy (DNA) may help to prevent or modify these compl... |
1 | TITLE: Healing and recurrence of active duodenal ulcer with nizatidine.ABSTRACT: Nizatidine, a new H2-receptor antagonist for treatment of duodenal ulcer disease, was evaluated in a unique two-phase, placebo-controlled, randomized, double-blind, multicenter clinical trial. Patients received either 150 mg nizatidine twi... |
1 | TITLE: A pilot study of piracetam in cuprophan hemodialysis.ABSTRACT: Twelve patients, 8 male and 4 female, aged from 26 to 70 years were studied. They were on hemodialysis (HD) 4 h three times weekly with cuprophan hollow fiber dialyzers (Gambro 120M) and dialysate containing 35 mEq/L of acetate. The study compares tw... |
1 | TITLE: Experience with terazosin administered in combination with other antihypertensive agents.ABSTRACT: In a randomized, double-blind, placebo-controlled, multicenter trial, the efficacy and safety of terazosin in combination with other antihypertensive agents were assessed using patients with inadequately controlled... |
1 | TITLE: A randomized, double-blind trial of a gonadotropin releasing-hormone agonist (leuprolide) with or without medroxyprogesterone acetate in the treatment of leiomyomata uteri.ABSTRACT: A randomized, double-blind study was performed on 16 women to compare the efficacy of daily subcutaneous (SC) injections of leuprol... |
0 | TITLE: Effects of infant nutrition on cholesterol synthesis rates.ABSTRACT: Nutrient effects on cholesterol fractional synthesis rates (FSR) in infancy by stable isotope determination have not been studied. We hypothesized that FSR is significantly reduced with high dietary cholesterol and phytoestrogen intake and incr... |
1 | TITLE: Benefits of lipid-lowering therapy in men with elevated apolipoprotein B are not confined to those with very high low density lipoprotein cholesterol.ABSTRACT: Do the benefits of intensive lipid-lowering therapy extend to patients with only borderline or moderately elevated levels of low density lipoprotein (LDL... |
1 | TITLE: Propofol anaesthesia in paediatric ambulatory patients: a comparison with thiopentone and halothane.ABSTRACT: The purpose of this study was to evaluate the haemodynamic changes during induction, as well as the speed and quality of recovery when propofol (vs thiopentone and/or halothane) was used for induction an... |
1 | TITLE: Caloric restriction per se is a significant factor in improvements in glycemic control and insulin sensitivity during weight loss in obese NIDDM patients.ABSTRACT: To examine the effects of caloric restriction, independent of differences in weight loss, on improvements in glycemic control, fasting insulin, and i... |
1 | TITLE: Clinical evaluation of topical isotretinoin in the treatment of actinic keratoses.ABSTRACT: Retinoids have been shown to improve the manifestations of skin photodamage, including actinic keratoses.The efficacy and tolerability of isotretinoin 0.1% cream in the treatment of actinic keratoses were evaluated in a r... |
1 | TITLE: Delay in progression of bone metastases in breast cancer patients treated with intravenous pamidronate: results from a multinational randomized controlled trial. The Aredia Multinational Cooperative Group.ABSTRACT: Bone metastases are a major cause of morbidity in breast cancer, resulting in complications that i... |
1 | TITLE: Effect of aprotinin on insulin sensitivity in non-insulin-dependent diabetes mellitus.ABSTRACT: It has been suggested that kallikrein-kinin system may influence carbohydrate metabolism via a kinin-mediated increment of insulin-mediated glucose uptake. To evaluate the effect of acute inhibition of the kallikrein-... |
1 | TITLE: Failure of cefonicid prophylaxis for infectious complications related to endoscopic retrograde cholangiopancreatography.ABSTRACT: We performed a controlled study to evaluate the role of cefonicid in preventing infectious complications related to retrograde cholangiopancreatography (ERCP). Consecutive patients we... |
1 | TITLE: Bupivacaine decreases epidural meperidine requirements after abdominal surgery.ABSTRACT: The purpose of this study was to determine the optimal of three concentrations of bupivacaine (0.0%, 0.05%, 0.10%) to add to an epidural infusion of meperidine (1 mg.ml-1) for postoperative pain relief.In this prospective, d... |
0 | TITLE: The role of the hypothalamic-pituitary-adrenal (HPA) axis in the regulation of blood pressure.ABSTRACT: The role of the HPA axis in blood pressure regulation was examined in 6 normal male volunteers by comparing haemodynamic and hormonal effects of placebo, captopril, and dexamethasone given in random order for ... |
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This is a dataset consisting of 993 titles + abstracts from the PubMed corpus. Each row has an label denoting whether the abstract comes from a randomized-controlled trial (RCT) or not.
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