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Energetics of the mechanics of human locomotion.
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10,000,101 |
The tensor fascia lata myocutaneous flap: experience with its use as a rotation flap.
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] |
10,000,102 |
The role of the primary care physician in rural mental health.
|
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] |
10,000,103 |
We are first physicians, then surgeons: a view of the whole patient.
|
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] |
10,000,104 |
Two-stage superficialis tendon reconstruction in severely damaged fingers.
|
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] |
10,000,105 |
In 16 fingers in 12 patients, where profundus tendon reconstruction was contraindicated due to soft tissue and distal joint changes, the superficialis tendon was reconstructed in two stages using a round silicone rod from the distal interphalangeal joint to the lumbrical level in the palm and profundus-superficialis tenorrhaphy as the first stage. The proximal end of the pedicled superficialis was used as the graft in the second stage. Fifteen fingers obtained a satisfactory result; one was a failure when the rod protruded through the skin. Two patients required a third surgical procedure: one a tenolysis at the superficialis-profundus junction, the other reattachment of the graft distally.
|
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] |
10,000,106 |
Aberrant sensory branch of the median nerve to the third web space--Case report.
|
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] |
10,000,107 |
Congenital fusion of the scaphoid and trapezium-case report.
|
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] |
10,000,108 |
Effect of marihuana on intraocular and blood pressure in glaucoma.
|
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10,000,109 |
Marihuana inhalation was accompanied by increased heart rate and decreased intraocular and blood pressure in 18 subjects with heterogenous glaucomas. The hypotensive effects appeared in 60 to 90 minutes as the decrease in intraocular pressure (IOP) appeared to follow the decrease in blood pressure. In addition to any local effect, the mechanism of lowered to any local effect, the mechanism of lowered IOP may also involve the decreased pressure perfusing the ciliary body vasculature as a result of the peripheral vasodilatory properties of marihuana. Postural hypotension, tachycardia, palpitations, and alterations in mental status occurred with such frequency as to mitigate against the routine used in the general glaucoma population. Our data indicate that further research should be directed to local means of delivering the ocular hypotensive cannabinoid to the glaucomatous eye.
|
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] |
10,000,110 |
Evidence for alteration in photoreceptor orientation.
|
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] |
10,000,111 |
The effect of incident light, its point of origin, and its magnitude on receptor orientation was determined. A non-invasive test of vision, the Stiles-Crawford Effect (SCE), was used to investigate retinal directional sensitivity and alignment. The simple act of monocular black patching for a period of three to five days caused marked reduction in directional sensitivity and/or apparent dispersal of alignments. Recovery occurred in a comparable time period in normal adults 20 to 50 years of age. Special painted iris contact lenses with displaced pupillary apertures were worn to investigate the factors influencing alignment. Both light induced effects which caused alignment to shift toward a displaced aperture, and mechanical factors resulting in other alignment shifts were recorded. Thus, retinal receptors and/or associated anatomic components are apparently phototropic and subject to multiple forces influencing their directionality and/or alignment, and the milieu of the retinal receptor is active.
|
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] |
10,000,112 |
[Risk factors in ischemic heart disease].
|
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] |
10,000,113 |
[Pharmacokinetic model studies of sulfamerazine in domestic mammals. 2. Elimination of Mebacid 200 and Mebacid tablets following oral, subcutaneous and intramuscular administration].
|
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] |
10,000,114 |
The mathematical foundations underlying pharmacokinetic testing and acceptance of medicaments for domestic mammals are expounded and discussed, with reference being made to examples of intramuscular, subcutaneous, and oral application of Mebacid 200 and Mebacid tablets. Elimination of sulphamerazine may be mathematically described by means of the following bi-exponential function: c = B x e-k2 x t -- A x e-k1 x t The concepts of the mono-compartmental model "Extravasal Application" can be claimed as being of basic validity. Blood levels established after intramuscular and subcutaneous application of sulphamerazine-sodium (Mebacid 200) were lower than those recorded after oral application of Mebacid tablets. The half-lives of elimination, following oral application to big animals of Mebacid tablets, were longer than those following intravenous application of comparable injection solution.
|
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] |
10,000,115 |
[Pharmacokinetic model studies of sulfamerazine in domestic mammals. 5. Resorption of Mebacid tablets in large animals].
|
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] |
10,000,116 |
The formula proposed by RITSCHEL (1973) for calculation of rates of resorption is explained and modified for use of the monocompartment model. Resorption rates were calculated for cattle, calf, horse, and sheep, with reference being made to the example of Mebacid tablets. The most favourable rate of resorption was established for calf.
|
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] |
10,000,117 |
[Problems in using radioactively labeled bacteria in animal experiments. 4. Distribution of activities in the mouse following intratracheal administration of labeled Pasteurella multocida].
|
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] |
10,000,118 |
Intratracheal administration of 3H-labelled, 14C-labelled, 59Fe-labelled or 125J-Labelled Pasteurella multicida germs to mice resulted in more or less differentiated, nuclide-dependent, distributions of radioactivity in blood, spleen, liver, lung, kidney, and gastro-intestinal tract. All distributions were comparable to those following subcutaneous application. Elimination of antigen from lungs and other organs could be characterised by an e-function, once a certain level of distribution had been reached. Some of the antigen was persistent in the lung not less than 14 days. Extremely high activity concentration and persistence was recordable, following the use of 59Fe complete antigen. Phagocytosis of Pasteurella multicida germs through alveolar macrophages of the lung was secured by autoradiography. Most of the antigen seemed to be discharged from the lungs through the digestive tract. Antigen distributions recorded from immunised and non-immunised mice seemed to suggest that the fate of antigen applied was affected by the kind of immunisation. No difference in antigen distribution between non-immunised and subcutaneously immunised animals were recordable, following intratracheal antigen application, but is was clearly recordable, following intratracheal immunisation. Elimination of antigen from the lungs of intratracheally immunised animals was found to occur faster than it did from non-immunised animals.
|
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] |
10,000,119 |
[Double aortic arch--a respiratory emergency].
|
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10,000,120 |
[The treatment of juvenile HBsAg-positive chronic active hepatitis (CAH) by means of BCG vaccine].
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10,000,121 |
[Emergency measures in acute arterial occlusion of the extremities].
|
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] |
10,000,122 |
[A quantitative theory of risk factors].
|
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] |
10,000,123 |
[Whole blood or blood component transfusion?].
|
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] |
10,000,124 |
[Urologic care - social hygiene aspects].
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] |
10,000,125 |
[Studies of calcium and phosphorus transport in the growing rat].
|
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] |
10,000,126 |
[Anaesthesiological technique for pregnant rabbit, with consideration of foetal condition (author's transl)].
|
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] |
10,000,127 |
Application of uninvolved propanidid-infusion anaesthesia to a rabbit in advanced pregnancy is reported in this paper. Uteroplacental circulation was found to be but slightly affected. The condition of the foetuses, consequently, may be considered sufficiently safe for intra-uterine experiments.
|
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] |
10,000,128 |
[Vaginaefixatio sacrospinalis vaginalis (Amreich II) for prolapse of vaginal stump (author's transl)].
|
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] |
10,000,129 |
Vaginaefixatio sacrospinalis vaginalis (Amreich II) was found to be a highly promising therapeutic approach to remedial action of prolapse of the vaginal stump. It is one of many possible abdominal or vaginal variants of surgical treatment. The surgical technique is described and evaluated with reference to the author's own patients.
|
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] |
10,000,130 |
[Detection of N-acetylneuraminic acid with long-time application of hormonal contraceptives (author's transl)].
|
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] |
10,000,131 |
The total level of N-acetylneuraminic acid in serum was found to be affected by long-time application of hormonal contraceptives. That effect appeared to depend on oestrogen. The problem of reversibility is discussed.
|
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] |
10,000,132 |
[New non-traumatic vacuum adapter with vaginal cylinder for hysterosalpingography (author's transl)].
|
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] |
10,000,133 |
Pathology of the urinary system in dogs from an endemic nephropathy (man) region of Bulgaria.
|
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] |
10,000,134 |
[Aeromonas hydrophila as a normal intestinal bacterium of the vampire bat (Desmodus rotundus)].
|
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] |
10,000,135 |
Radial-maze performance in the rat following lesions of posterior neocortex.
|
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] |
10,000,136 |
The present experiment was designed t investigate the role of posterior neocortex (areas 17, 18 and 18a) in the maintenance of performance on the radial maze. Following training to criterion on the 8-arm radial maze, rats received either sham operations, bilateral eye enucleations, lesions of posterior neocortex, or combined enucleations and lesions of posterior neocortex. While the enucleated animals with intact brains showed a slight, but significant performance decrement relative to the sham-operated group, the other two groups, with lesions of areas 17, 18 and 18a, each showed a massive deficit. This large deficit was observed even in the group in which both the eyes and neocortex had been removed. These results suggest that the visual projection areas of cortex not only play an important role in the maintenance of accurate radial-maze performance in sighted animals, but that the integrity of these areas is necessary for the maintenance fo criterion performance in blind animals.
|
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] |
10,000,137 |
Differential effects of prefrontal cortex ablation in neonatal, juvenile, and young adult rats.
|
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] |
10,000,138 |
Rats sustaining lesions restricted to the medial (MF) or the orbital (OF) pre-frontal cortex at various ages (10, 25, 40, or 60 days postnatally) were tested as adults on a series of behavioral tasks that are known to be sensitive to such lesions in adults. On spatial alternation learning, both the 40- and 60-day MF operates were seriously impaired, whereas neither the 10- nor the 25-day MF operates differed from control. On a hoarding task, 25- and 60-day MF operates hoarded less food than either controls or 10-day MF operates. Lesions of OF cortex in males at 40 or 60 days of age produced a significant increase in running-wheel activity; OF lesions in both sexes at 25 days of age or later produced a decrease in the rate of continuous reinforcement reacquisition (following experience with differential reinforcement of low rates of responding and bar-press extinction) relative to controls, whereas 10-day OF operates did not differ from controls on either task. Thus, rats with lesions of either frontal area at 10 days of age showed complete behavioral sparing on all measures. The effects of lesions at later ages varied with the behavioral tasks employed and with lesion locus. Although the 10-day operates received a somewhat longer postoperative recovery interval than most of the later operates, these results cannot be explained on the basis of recovery time alone. A control group of 60-day operates with the same recovery interval as the 10-day operates did not differ on any measure from the 60-day operates with shorter recovery intervals.
|
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] |
10,000,139 |
Supraoptic nucleus of the Brattleboro rat has an altered afferent noradrenergic input.
|
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] |
10,000,140 |
The distribution of fluorescent varicosities in the supraoptic nucleus of Brattleboro rats was compared to that in normal rats. The Brattleboro rat, which is characterized by a genetic absence of vasopressin, had fewer fluorescent varicosities in apposition to the vasopressin-deficient perikarya. The oxytocin-producing neurons in the same nucleus were hyperinnervated. These data suggest that the target neuron peptide (vasopressin) is necessary for the maintenance of normal noradrenergic innervation patterns.
|
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] |
10,000,141 |
Preservation of orthographic knowledge in aphasia.
|
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] |
10,000,142 |
Impairment of right brain-damaged patients on a linguistic cognitive task.
|
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10,000,143 |
Forty right hemisphere-damaged patients and 35 normal controls were given five language tests, the Token test, a naming to description test, the Reporter's test, a word fluency test and a sentence anagram test. The sentence anagram test was the only measure on which right hemisphere patients performed significantly more poorly than control patients. It is surmised that this impairment may be indicative of a direct right hemisphere participation in linguistic performances.
|
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] |
10,000,144 |
[Congenital contractural arachnodactyly].
|
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] |
10,000,145 |
[Marfan's and the Ehlers-Danlos syndrome: a proposal for a pathogenetic explanation (author's transl)].
|
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] |
10,000,146 |
[Mitral valve prolapse syndrome associated with severe arrhythmia in a 6-year-old girl with Marfan's syndrome].
|
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] |
10,000,147 |
Marfan's syndrome presenting with achalasia of the oesophagus. A case report.
|
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] |
10,000,148 |
Patients with Marfan's syndrome usually present with a positive family history and/or cardiovascular or ocular abnormalities. A patient with Marfan's syndrome who presented with achalasia of the oesophagus is described.
|
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] |
10,000,149 |
Achalasia in siblings. Clinical and genetic aspects.
|
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] |
10,000,150 |
Achalasia is rare in children; less than 2% of all patients with achalasia are less than 6 years old. Familial achalasia is extraordinarily rare, for an exhaustive search of the world literature yielded only 31 cases. Two additional cases are reported here. Based on an analysis of the reported cases in the literature coupled with our two cases, we have observed that familial achalasia is likely transmitted as an autosomal recessive trait. We recommend that all siblings of children with confirmed achalasia should either be studied by contrast roentgenography or be monitored closely for clinical signs of achalasia, especially if they are products of consanguineous parents.
|
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] |
10,000,151 |
[Achalasia of the esophagus and cancer of the gastric stump].
|
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] |
10,000,152 |
Symptomatic relapse after oral vancomycin therapy of antibiotic-associated pseudomembranous colitis.
|
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10,000,153 |
Twenty patients with antimicrobiol-associated diarrhea had a symptomatic relapse after oral vancomycin therapy. All patients had stool examinations which implicated C. difficile as the causative agent, and 16 had pseudomembranous colitis. Clinical courses were characterized by resolution of symptoms with recurrence of diarrhea at 4--21 days after vancomycin was discontinued. Studies of stools collected sequentially showed that vancomycin failed to eliminate C. difficile despite susceptibility to this agent with in vitro testing. A review of our records shows the incidence os symptomatic relapse is approximately 14%. This experience emphasizes the importance of adequate follow-up in patients treated with oral vancomycin for antibiotic-associated diarrhea or colitis due to C. difficile.
|
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] |
10,000,154 |
Antibiotic-associated pseudomembranous colitis: 1980.
|
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] |
10,000,155 |
Component concentrations and activation of the complement system in neonatal illness: a preliminary study of necrotizing enterocolitis.
|
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10,000,156 |
Determinations of C3, C4, and C5 concentrations by radial immunodiffusion, and assays for the activation products of C3, C3c and C3d by counterimmunoelectrophoresis, were performed on 80 infants. Seven nonbacteremic preterm infants with necrotizing enterocolitis (NEC) or probable NEC (PNEC) were found at the time of diagnosis to have a significantly lower mean concentration of C3 (P less than 0.05, 1-tailed) without C3 activation when compared to other noninfected preterm infants. Ten full-term and 63 preterm infants were studied prospectively during the first days of life, and were then followed for the postnatal development of localized or systemic infection. Assays for the detection of C3 activation products were negative in all these infants. Four preterm infants who developed PNEC after 5 or more days without clinical illness had low original concentrations of complement components. The pathogenesis of NEC may not involve primarily complement activation, and susceptibility to this condition may be related to pre-existing deficiencies in complement component concentrations relative to gestational age, or to defective activation of C3 in the presence of certain bacterial species and strains.
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-0.011701773852109909,
0.021735770627856255,
0.06668899953365326,
0.033870846033096313
] |
10,000,157 |
The effect of antimicrobial agents on human intestinal flora, with particular reference to Bacteroides species.
|
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] |
10,000,158 |
The composition of human fecal flora, the methods for its study, and the changes in the normal colonic flora caused by orally administered lincomycins, tetracyclins and aminoglycosides are reviewed. Recent studies concerning the effect of the benzo-diazaborine derivative CG 3401 on human fecal flora, especially Bacteroides species, are reported.
|
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] |
10,000,159 |
Proctoscopy in infancy with reference to its use in necrotising enterocolitis.
|
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] |
10,000,160 |
Experience with the fairly simple and safe technique of proctoscopy in an infant using an ordinary auroscope is reported. The use of the auroscope showed the presence of a frank colitis in 13 of 14 consecutive cases of necrotising enterocolitis. A prospective study was made during a 6-month period of 51 infants with diarrhoea referred to a gastroenterology isolation unit; proctoscopic findings that suggested colitis were found in 10. Of these, 3 appeared to have necrotising enterocolitis; 3 had salmonella or shigella dysentery; in 3 of the remaining 4 the findings were localised to the anus, with normal mucosa above. This was attributed to a mild rectal prolapse on straining. There was no correlation between the severity of the diarrhoea and the presence of colitis. Proctoscopy is safe and valuable in the early diagnosis of necrotising enterocolitis. It is also helped in assessing the progress of the disease.
|
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] |
10,000,161 |
Neonatal necrotizing enterocolitis: the relation of age at the time of onset to prognosis.
|
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] |
10,000,162 |
A study was undertaken to evaluate the predisposing factors, age at the time of onset and prognosis of neonatal necrotizing enterocolitis in 62 patients treated in a neonatal intensive care unit during a 5-year period (1974-78). Because of a peak frequency during the first week of life, the cases were divided into those of early-onset illness (appearing within the first week of life) and those of late-onset illness (appearing after this week). The main differences between the two groups were in the age at the time of the first enteric feeding (1.6 +/- 0.9 d v. 40 +/- 2.4 d [mean +/- one standard deviation]; P less than 0.001) and the interval between this feeding and the onset of symptoms (3.0 +/- 1.5 d v. 10.6 +/- 6.0 d; P less than 0.01). Furthermore, the early-onset illness was more severe, more often necessitating surgical intervention and carrying a higher mortality, than the late-onset illness. Thus, this study demonstrates that there are two forms of neonatal necrotizing enterocolitis, differing in time of appearance after birth as well as in severity and prognosis.
|
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] |
10,000,163 |
Varicoid carcinoma of the esophagus. Report of a patient with adenocarcinoma and review of the literature.
|
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] |
10,000,164 |
A patient with varicoid carcinoma of the esophagus is reported. These tumors differ from classical esophageal carcinoma and have some resemblance to esophageal varices in their radiological and endoscopic appearances. Dysphagia is generally not the presenting symptom. The histological picture in our patient was that of a poorly differentiated adenocarcinoma with areas of signet-cell carcinoma. This is an exceptional finding since all previously reported cases of varicoid carcinoma of the esophagus have been squamous cell carcinomas.
|
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] |
10,000,165 |
[A case of downhill varices of the esophagus (author's transl)].
|
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] |
10,000,166 |
[Percutaneous transhepatic obliteration of gastroesophageal varices (author's transl)].
|
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] |
10,000,167 |
Extraction of light filth from barley, oatmeal, and mixed dry infant cereals: collaborative study.
|
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] |
10,000,168 |
A new method has been developed for the extraction of light filth from oatmeal, barley, and mixed dry infant cereals which involves HCl digestion followed by wet sieving. The residue is defatted in a paper cup, using isopropanol, and transferred to a 2 L Wildman trap flask with 40% isopropanol. Filth elements are extracted with light mineral oil. Interlaboratory studies resulted in 92 and 86% average recoveries of rodent hairs and insect fragments, respectively. The proposed method has been adopted as official first action.
|
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] |
10,000,169 |
[Anti HBc-IgM in acute and chronic hepatitis B].
|
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] |
10,000,170 |
Purine and pyrimidine nucleotide patterns of normal, differentiating, and regenerating liver and of hepatomas in rats.
|
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] |
10,000,171 |
Kinetics of BCG mediated tumour cell destruction in the rat.
|
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] |
10,000,172 |
The effect of scandium on the tissue distribution of Ga-67 in normal and tumor-bearing rodents.
|
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] |
10,000,173 |
In rats and mice the intravenous administration of scandium before or with Ga-67 produces an increase in Ga-67 excretion and bone deposition, coupled with pronounced decreases in the uptake of Ga-67 in soft tissues. These effects result from the blocking by scandium of Ga-67 plasma-protein binding sites, which forces Ga-67 into an unbound or loosely bound state. This increases Ga-67 excretion and bone deposition, which in turn acts to produce greatly reduced Ga-67 uptake in soft tissues. When tumor-bearing rats and mice are administered scandium, similar effects occur, but the uptake of Ga-67 by tumor tissue remains unchanged. This suggests that Ga-67 enters tumor and normal soft tissues by different routes. With tumor, an unbound or loosely bound form of gallium is primarily involved, whereas with normal soft tissues this route is apparently of minor importance.
|
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] |
10,000,174 |
[Use of radionuclides to study structural differences in mitochondrial and lysosomal membranes of normal and neoplastic cells].
|
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] |
10,000,175 |
Radionuclids 111In, 67Ga and Na275 SeO3 were seen accumulated in subcellular structures of transplanted and carcinogen-induced tumors of mice and rats. Lysosomes and mitochondria of tumor cells were labeled much less compared to the normal tissue. Maximal radioactivity was found in mitochondrial or lysosomal membranes, both in normal and tumor cells. It is suggested that radionuclids may be useful in study of conformational changes in normal membrane systems in the course of malignisation.
|
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] |
10,000,176 |
Analysis of loss of nuclear RNA in azo dye-induced hepatoma by DNA-RNA competitive hybridization.
|
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] |
10,000,177 |
DNA-RNA hybridization studies, using nuclear RNA's (nRNA's) labeled in vivo and in vitro with high specific radioactivities, were performed to compare the nRNA populations of normal rat liver, livers treated with 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB), and 3'-Me-DAB-induced hepatomas. The study with normal liver nRNA labeled by i.p. injection of [3H]orotic acid indicated that the nuclei of a 3'-Me-DAB-induced transplanted hepatoma, AH136B, lacked some RNA species present in normal liver nuclei. No qualitative difference in thee RNA populations was seen between normal liver and the livers of rats fed a carcinogenic amount of 3'-Me-DAB, either alone or in combination with 4-nitrostilbene which enhanced the azo dye carcinogenesis. Then, nRNA's of both normal liver and AH136B hepatoma were labeled in vitro by phosphorylation with polynucleotide kinase and adenosine 5'-[gamma-32P]triphosphate. The competitive hybridization with 32P-labeled normal liver nRNA was competed, and the deletion of RNA in the nuclei of AH136B hepatoma or 3'-Me-DAB-induced primary hepatoma was estimated to be 15% or more in the measure of radioactivity of the hybridized normal liver nRNA. 32P-labeled AH136B hepatoma nRNA was completed completely by liver nRNA's, suggesting that no unique RNA species were present in the hepatoma nuclei.
|
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] |
10,000,178 |
Surface proteins in normal and transformed rat liver epithelial cells in culture.
|
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] |
10,000,179 |
The pattern of surface proteins of different types of normal and transformed rat liver cells have been studied in culture by means of lactoperoxidase-catalysed iodination procedures, followed by SDS-gel electrophoresis. The cells examined were primary cultures of epithelial liver cells, long-term cultures of epithelial liver cells, in vitro transformed epithelial liver cell lines and liver tumour-cell lines; mesenchymal cells from liver and skin were also examined. The principal surface proteins of primary cultures of epithelial cells from adult or neonatal rats had components with mol. wts of 140,000-160,000, 100,000 and 40,000-70,000. A band that had the same position as fibronectin from mesenchymal cells was also present and this band, as well as other iodinated components, were less sensitive to trypsin than fibroblastic fibronectin. A similar pattern of iodinated proteins was seen in long-term cultures of epithelial liver cells, with a great reduction in the number and intensity of the bands in the mol. wt region below 100,000. Almost all the in vitro transformed and tumour epithelial cell lines contain a protein with a mol. wt 135,000 as one of the major iodinated bands, and in contrast to the observation in transformed fibroblasts, the fibronectin was retained by most of these transformed cell lines.
|
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] |
10,000,180 |
Differentiation of normal and inducible rat liver aldehyde dehydrogenases by disulfiram inhibition in vitro.
|
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] |
10,000,181 |
Protective effects of DL-tryptophan on benzidine-induced hepatic tumor in mice.
|
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] |
10,000,182 |
This study was undertaken to evaluate the carcinogenic effect of benzidine on the urinary bladder of mice, and the effect of DL-tryptophan on the induction of bladder cancer. Benzidine plus DL-tryptophan or benzidine alone mixed with a commercial basal diet was fed to groups of ICR strain female mice for 20 weeks, after a glass bead had been inserted into the bladder. Control mice were fed the basal diet throughout the experimental period. All the surviving mice were killed 63 weeks after start of the study. Benzidine administered with or without DL-tryptophan did not induce tumors of the urinary bladder in these mice. Hepatomas developed in 34 of 41 mice (82.9%) fed benzidine and in 24 of 51 mice (47.1%) fed benzidine with tryptophan. DL-Tryptophan counteracted the effect of benzidine and significantly reduced the development of hepatomas.
|
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] |
10,000,183 |
[Distribution and movement of concanavalin A receptors on the surfaces of cells in suspension].
|
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] |
10,000,184 |
Normal mouse fibroblasts, transformed mouse fibroblasts (L strain), the ascite hepatoma cells (strain 22), the Krebs II ascite cells, and mouse spleen lymphocytes were incubated in suspension in the medium containing concanavalin A which is capable of crosslinking definite groups of surface receptors. Surface-attached ligands were revealed by both direct and indirect immunofluorescent methods. The incubation of all the cell types with that ligand-induced patching rather than capping of corresponding surface receptors. Colcemid had no effect on the ligand-induced redistribution of receptors.
|
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] |
10,000,185 |
In vitro demonstration of in situ autologous tumour-cell cytotoxicity in MSV-induced tumours in A/SN mice.
|
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] |
10,000,186 |
Moloney sarcoma-virus (MSV)-induced tumours in A/Sn mice have been dispersed with collagenase and DNase 8-15 days after virus inoculation, and both "sarcoma" and inflammatory cells separated by sedimentation velocity and adherence techniques. The isolated "sarcoma" cells had the morphological characteristics of atypical cells (i.e. cytoplasmic blebbing, vacuolization and prominent nucleoli) and were easily adapted to in vitro growth. As few as 2 x 10(3) of these cells inoculated i.m. produced new tumours within 8 days of injection in both syngeneic and allogeneic mice. Also, cell-free supernatant from "sarcoma"-cell cultures produced tumours, indicating that the successful transplantation of the "sarcoma" cells was probably due to production of infective virus. Cells cytotoxic in vitro against the "sarcoma" cells were present within both spleen and tumour of the tumour donors, but not in the spleens of normal mice. The cytotoxicity was specific against virus-infected cells, since in a mixture of virus-positive (gp 70) and virus-negative cells, positive cells were removed while negative cells were not affected, as measured by a visual cytotoxicity assay using immunostaining. Although T cells could be isolated from the MSV-induced tumours, these cells did not appear to mediate the cytotoxicity detected against the MSV "sarcoma" cells. These results suggest that early MSV infections might be sensitive to cytotoxic mechanisms distinct from those reported with established MLV- or MSV-induced tumour lines.
|
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] |
10,000,187 |
[Reproductive ability of germfree ICR female mice (author's transl)].
|
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] |
10,000,188 |
Reproductive ability of germfree and conventional female ICR mice was examined. Litter size and number of fetuses of germfree ICR mice kept in Facility A were smaller than those of Jcl: ICR mice. No difference was seen in oestrous cycle, pregnant rate, gestation period, weaning rate and number of corpora lutea between germfree and conventional mice. The small litter size of germfree mice seemed to be associated with early embryonic death before implantation. On the other hand, litter size of ex-germfree mice did not increase after conventionalization in Facility B.
|
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] |
10,000,189 |
Ovum capture and fertility following microsurgical fimbriectomy in the rabbit.
|
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] |
10,000,190 |
Microsurgical fimbriectomy with removal of the fimbria ovarica was performed on one side in 19 rabbits. The other tube was left intact as a control. In 10 animals the new ostium was left free, some distance from the ovary. In the remainder, the ostium was fixed to the ovarian capsule. Three animals with a fixed ostium developed mild hydrosalpinx even though the neostomy was patent. Of the remaining 16 rabbits, 15 conceived and became pregnant in both uterine horns. There was no significant difference between nidation index on the two sides. It is concluded that intact fimbriae with a fimbria ovarica are not essential for normal ovum capture. It is therefore suggested that methods for clinical salpingostomy may require re-evaluation.
|
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] |
10,000,191 |
Preimplantation loss in inbred strains of rats.
|
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] |
10,000,192 |
Contact patterns between cytotrophoblast and decidual cells in human implantation site.
|
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] |
10,000,193 |
To elucidate the mechanism of trophoblastic invasion, implantation sites removed from human uteri of early gestational stages of 7 to 10 week were investigated by electron microscopy. Almost all trophoblast cells which penetrated the fibrinoid layer and invaded into decidual tissue were cytotrophoblast cells, and abundant close-contacts between the cytotrophoblast and decidual cells were recognized in this site. The close-contact patterns which were composed of simple apposition, cytoplasmic projection from both cells and mixture of those without fusion were classified into five types. At the time of close-contact, the decidual cells showed the altered structures in various degrees, but never did they alter so strongly as to appear to have died completely. Thus, it is deduced that the influence from cytotrophoblast cells did not cause the destruction of the decidual cells but only biological inactivation of the cells. It is of great significance to the immunological problem between fetus and mother that the cytotrophoblast cells which are fetal epithelial cells can be in close-contact with decidual cells which are maternal stromal cells. Further confirmation relating to the production and transcellular transfer patterns of the information materials should be awaited in future.
|
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] |
10,000,194 |
Voluntary intake of oat straw by beef cattle as influenced by urea supplementation, given individually in a concentrate or by group-feeding in a feedblock.
|
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] |
10,000,195 |
Studies on search for a promising immunopotentiative substance for treatment of leprosy. (II) On several biological actions of bamboo grass extracts.
|
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-0.037434227764606476,
0.05795571953058243,
0.08071756362915039
] |
10,000,196 |
A note on sandflies of Pauri Garhwal (Uttar Pradesh), India.
|
[
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0.1237846314907074
] |
10,000,197 |
Cimetidine and thrombocytopenia.
|
[
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] |
10,000,198 |
Cimetidine-associated thrombocytopenia and leukopenia.
|
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] |
10,000,199 |
Immune thrombocytopenia in severe neonatal infections.
|
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