Dataset Viewer
pid
stringlengths 19
29
| Title
stringlengths 6
475
| Text
stringlengths 473
7.51k
| Prompt
stringlengths 235
7.27k
| Description
stringlengths 7
7.01k
| Subject
stringclasses 27
values | Keywords
stringlengths 3
4.85k
|
|---|---|---|---|---|---|---|
doi:10.11588/data/04HPWW
|
Cellular correlates of gray matter volume changes in magnetic resonance morphometry identified by two-photon microscopy [Dataset]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'This dataset accompanies the article of the same title in the journal Scientific Reports. It includes a) spreadsheets of data values for each plot in the main figures, b) all raw image data from Two-Photon in vivo microscopy (2pii) c) Custom code d) representative subsets of segmentation label images, coordinates of reidentified nuclei and corresponding magnetic resonance images from all timepoints of one animal (ID S8).' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Correlative Neuroimaging; Microscopy; VBM; Voxel-based Morphometry'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Cellular correlates of gray matter volume changes in magnetic resonance morphometry identified by two-photon microscopy [Dataset]' Description:'This dataset accompanies the article of the same title in the journal Scientific Reports. It includes a) spreadsheets of data values for each plot in the main figures, b) all raw image data from Two-Photon in vivo microscopy (2pii) c) Custom code d) representative subsets of segmentation label images, coordinates of reidentified nuclei and corresponding magnetic resonance images from all timepoints of one animal (ID S8).' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
This dataset accompanies the article of the same title in the journal Scientific Reports. It includes a) spreadsheets of data values for each plot in the main figures, b) all raw image data from Two-Photon in vivo microscopy (2pii) c) Custom code d) representative subsets of segmentation label images, coordinates of reidentified nuclei and corresponding magnetic resonance images from all timepoints of one animal (ID S8).
|
Medicine, Health and Life Sciences
|
Correlative Neuroimaging; Microscopy; VBM; Voxel-based Morphometry
|
doi:10.11588/data/0Z7H1X
|
Robust logistic regression to narrow down the winner's curse for rare and recessive susceptibility variants [Source Code]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Logistic regression is the most common technique used for genetic case-control association studies. A disadvantage of standard maximum likelihood estimators of the genotype relative risk (GRR) is their strong dependence on outlier subjects, for example, patients diagnosed at unusually young age. Robust methods are available to constrain outlier influence, but they are scarcely used in genetic studies. This article provides a non-intimidating introduction to robust logistic regression, and investigates its benefits and limitations in genetic association studies. We applied the bounded Huber and extended the R package ‘robustbase’ with the re-descending Hampel functions to down-weight outlier influence. Computer simulations were carried out to assess the type I error rate, mean squared error (MSE) and statistical power according to major characteristics of the genetic study and investigated markers. Simulations were complemented with the analysis of real data. Both standard and robust estimation controlled type I error rates. Standard logistic regression showed the highest power but standard GRR estimates also showed the largest bias and MSE, in particular for associated rare and recessive variants. For illustration, a recessive variant with a true GRR=6.32 and a minor allele frequency=0.05 investigated in a 1000 case/1000 control study by standard logistic regression resulted in power=0.60 and MSE=16.5. The corresponding figures for Huber-based estimation were power=0.51 and MSE=0.53. Overall, Hampel- and Huber-based GRR estimates did not differ much. Robust logistic regression may represent a valuable alternative to standard maximum likelihood estimation when the focus lies on risk prediction rather than identification of susceptibility variants.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'genetic association study; re-descending Hampel function; robust logistic regression; winner’s curse'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Robust logistic regression to narrow down the winner's curse for rare and recessive susceptibility variants [Source Code]' Description:'Logistic regression is the most common technique used for genetic case-control association studies. A disadvantage of standard maximum likelihood estimators of the genotype relative risk (GRR) is their strong dependence on outlier subjects, for example, patients diagnosed at unusually young age. Robust methods are available to constrain outlier influence, but they are scarcely used in genetic studies. This article provides a non-intimidating introduction to robust logistic regression, and investigates its benefits and limitations in genetic association studies. We applied the bounded Huber and extended the R package ‘robustbase’ with the re-descending Hampel functions to down-weight outlier influence. Computer simulations were carried out to assess the type I error rate, mean squared error (MSE) and statistical power according to major characteristics of the genetic study and investigated markers. Simulations were complemented with the analysis of real data. Both standard and robust estimation controlled type I error rates. Standard logistic regression showed the highest power but standard GRR estimates also showed the largest bias and MSE, in particular for associated rare and recessive variants. For illustration, a recessive variant with a true GRR=6.32 and a minor allele frequency=0.05 investigated in a 1000 case/1000 control study by standard logistic regression resulted in power=0.60 and MSE=16.5. The corresponding figures for Huber-based estimation were power=0.51 and MSE=0.53. Overall, Hampel- and Huber-based GRR estimates did not differ much. Robust logistic regression may represent a valuable alternative to standard maximum likelihood estimation when the focus lies on risk prediction rather than identification of susceptibility variants.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Logistic regression is the most common technique used for genetic case-control association studies. A disadvantage of standard maximum likelihood estimators of the genotype relative risk (GRR) is their strong dependence on outlier subjects, for example, patients diagnosed at unusually young age. Robust methods are available to constrain outlier influence, but they are scarcely used in genetic studies. This article provides a non-intimidating introduction to robust logistic regression, and investigates its benefits and limitations in genetic association studies. We applied the bounded Huber and extended the R package ‘robustbase’ with the re-descending Hampel functions to down-weight outlier influence. Computer simulations were carried out to assess the type I error rate, mean squared error (MSE) and statistical power according to major characteristics of the genetic study and investigated markers. Simulations were complemented with the analysis of real data. Both standard and robust estimation controlled type I error rates. Standard logistic regression showed the highest power but standard GRR estimates also showed the largest bias and MSE, in particular for associated rare and recessive variants. For illustration, a recessive variant with a true GRR=6.32 and a minor allele frequency=0.05 investigated in a 1000 case/1000 control study by standard logistic regression resulted in power=0.60 and MSE=16.5. The corresponding figures for Huber-based estimation were power=0.51 and MSE=0.53. Overall, Hampel- and Huber-based GRR estimates did not differ much. Robust logistic regression may represent a valuable alternative to standard maximum likelihood estimation when the focus lies on risk prediction rather than identification of susceptibility variants.
|
Medicine, Health and Life Sciences
|
genetic association study; re-descending Hampel function; robust logistic regression; winner’s curse
|
doi:10.11588/data/0Z7H1X
|
Robust logistic regression to narrow down the winner's curse for rare and recessive susceptibility variants [Source Code]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Logistic regression is the most common technique used for genetic case-control association studies. A disadvantage of standard maximum likelihood estimators of the genotype relative risk (GRR) is their strong dependence on outlier subjects, for example, patients diagnosed at unusually young age. Robust methods are available to constrain outlier influence, but they are scarcely used in genetic studies. This article provides a non-intimidating introduction to robust logistic regression, and investigates its benefits and limitations in genetic association studies. We applied the bounded Huber and extended the R package ‘robustbase’ with the re-descending Hampel functions to down-weight outlier influence. Computer simulations were carried out to assess the type I error rate, mean squared error (MSE) and statistical power according to major characteristics of the genetic study and investigated markers. Simulations were complemented with the analysis of real data. Both standard and robust estimation controlled type I error rates. Standard logistic regression showed the highest power but standard GRR estimates also showed the largest bias and MSE, in particular for associated rare and recessive variants. For illustration, a recessive variant with a true GRR=6.32 and a minor allele frequency=0.05 investigated in a 1000 case/1000 control study by standard logistic regression resulted in power=0.60 and MSE=16.5. The corresponding figures for Huber-based estimation were power=0.51 and MSE=0.53. Overall, Hampel- and Huber-based GRR estimates did not differ much. Robust logistic regression may represent a valuable alternative to standard maximum likelihood estimation when the focus lies on risk prediction rather than identification of susceptibility variants.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'genetic association study; re-descending Hampel function; robust logistic regression; winner’s curse'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Robust logistic regression to narrow down the winner's curse for rare and recessive susceptibility variants [Source Code]' Description:'Logistic regression is the most common technique used for genetic case-control association studies. A disadvantage of standard maximum likelihood estimators of the genotype relative risk (GRR) is their strong dependence on outlier subjects, for example, patients diagnosed at unusually young age. Robust methods are available to constrain outlier influence, but they are scarcely used in genetic studies. This article provides a non-intimidating introduction to robust logistic regression, and investigates its benefits and limitations in genetic association studies. We applied the bounded Huber and extended the R package ‘robustbase’ with the re-descending Hampel functions to down-weight outlier influence. Computer simulations were carried out to assess the type I error rate, mean squared error (MSE) and statistical power according to major characteristics of the genetic study and investigated markers. Simulations were complemented with the analysis of real data. Both standard and robust estimation controlled type I error rates. Standard logistic regression showed the highest power but standard GRR estimates also showed the largest bias and MSE, in particular for associated rare and recessive variants. For illustration, a recessive variant with a true GRR=6.32 and a minor allele frequency=0.05 investigated in a 1000 case/1000 control study by standard logistic regression resulted in power=0.60 and MSE=16.5. The corresponding figures for Huber-based estimation were power=0.51 and MSE=0.53. Overall, Hampel- and Huber-based GRR estimates did not differ much. Robust logistic regression may represent a valuable alternative to standard maximum likelihood estimation when the focus lies on risk prediction rather than identification of susceptibility variants.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Logistic regression is the most common technique used for genetic case-control association studies. A disadvantage of standard maximum likelihood estimators of the genotype relative risk (GRR) is their strong dependence on outlier subjects, for example, patients diagnosed at unusually young age. Robust methods are available to constrain outlier influence, but they are scarcely used in genetic studies. This article provides a non-intimidating introduction to robust logistic regression, and investigates its benefits and limitations in genetic association studies. We applied the bounded Huber and extended the R package ‘robustbase’ with the re-descending Hampel functions to down-weight outlier influence. Computer simulations were carried out to assess the type I error rate, mean squared error (MSE) and statistical power according to major characteristics of the genetic study and investigated markers. Simulations were complemented with the analysis of real data. Both standard and robust estimation controlled type I error rates. Standard logistic regression showed the highest power but standard GRR estimates also showed the largest bias and MSE, in particular for associated rare and recessive variants. For illustration, a recessive variant with a true GRR=6.32 and a minor allele frequency=0.05 investigated in a 1000 case/1000 control study by standard logistic regression resulted in power=0.60 and MSE=16.5. The corresponding figures for Huber-based estimation were power=0.51 and MSE=0.53. Overall, Hampel- and Huber-based GRR estimates did not differ much. Robust logistic regression may represent a valuable alternative to standard maximum likelihood estimation when the focus lies on risk prediction rather than identification of susceptibility variants.
|
Medicine, Health and Life Sciences
|
genetic association study; re-descending Hampel function; robust logistic regression; winner’s curse
|
doi:10.11588/data/10028
|
Depletion of the chromatin looping proteins CTCF and cohesin causes chromatin compaction [Dataset]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Simulations using an advanced version of the Dynamic Loop model were performed to investigate the mechanisms responsible for the experimental finding that the reduction of the chromatin looping proteins CTCF and cohesin leads to chromatin compaction.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'BFM; Chromatin; Chromatin folding; Chromatin looping; Cohesin; CTCF; DNA; Dynamic Loop model; Monte-Carlo simulations; Polymer'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Depletion of the chromatin looping proteins CTCF and cohesin causes chromatin compaction [Dataset]' Description:'Simulations using an advanced version of the Dynamic Loop model were performed to investigate the mechanisms responsible for the experimental finding that the reduction of the chromatin looping proteins CTCF and cohesin leads to chromatin compaction.' Subject:'Medicine, Health and Life Sciences; Physics. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Simulations using an advanced version of the Dynamic Loop model were performed to investigate the mechanisms responsible for the experimental finding that the reduction of the chromatin looping proteins CTCF and cohesin leads to chromatin compaction.
|
Medicine, Health and Life Sciences
|
BFM; Chromatin; Chromatin folding; Chromatin looping; Cohesin; CTCF; DNA; Dynamic Loop model; Monte-Carlo simulations; Polymer
|
doi:10.11588/data/10028
|
Depletion of the chromatin looping proteins CTCF and cohesin causes chromatin compaction [Dataset]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Simulations using an advanced version of the Dynamic Loop model were performed to investigate the mechanisms responsible for the experimental finding that the reduction of the chromatin looping proteins CTCF and cohesin leads to chromatin compaction.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'BFM; Chromatin; Chromatin folding; Chromatin looping; Cohesin; CTCF; DNA; Dynamic Loop model; Monte-Carlo simulations; Polymer'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Depletion of the chromatin looping proteins CTCF and cohesin causes chromatin compaction [Dataset]' Description:'Simulations using an advanced version of the Dynamic Loop model were performed to investigate the mechanisms responsible for the experimental finding that the reduction of the chromatin looping proteins CTCF and cohesin leads to chromatin compaction.' Subject:'Medicine, Health and Life Sciences; Physics. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Simulations using an advanced version of the Dynamic Loop model were performed to investigate the mechanisms responsible for the experimental finding that the reduction of the chromatin looping proteins CTCF and cohesin leads to chromatin compaction.
|
Physics
|
BFM; Chromatin; Chromatin folding; Chromatin looping; Cohesin; CTCF; DNA; Dynamic Loop model; Monte-Carlo simulations; Polymer
|
doi:10.11588/data/10039
|
Factors affecting the uptake of HIV testing among men
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'This study aimed to explore factors shaping the decision to undergo Human Immunodeficiency Virus (HIV) testing among men in rural Burkina Faso. The study took place in 2009 in the Nouna Health District and adopted a triangulation mixed methods design. Nouna Health District, is located in north-western Burkina Faso. At the time of the study, the district had a population of approximately 311,000 distributed in 300 villages and included 31 first-line facilities, Centres de Santé et de Promotion Sociale (CSPS)and one district hospital. A sub-portion of the district has been part of a Health and Demographic Surveillance System (HDSS) for over 15 years. Following national policy, starting in 2006, all CSPS were equipped to offer HIV counseling and testing to pregnant women and their partners as the entry point to PMTCT services. Explicit efforts were made to address the need for couple counseling and testing, encouraging spouses to be tested together with their pregnant wives. In addition, providers were encouraged to offer testing to anyone requesting it and/or to anyone who presented with potential symptoms of infection. The quantitative component relied on data collected through a structured survey on a representative sample of 1130 households. The qualitative component relied on 38 in-depth interviews, with men purposely selected to represent variation in testing decision, age, and place of residence. Household survey data were analyzed using Stata 11 (Stata Corporation, Texas, USA). The outcome variable was defined as “having tested for HIV”.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Burkina Faso; HIV testing; men; mixed-methods; sub-Saharan Africa'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Factors affecting the uptake of HIV testing among men' Description:'This study aimed to explore factors shaping the decision to undergo Human Immunodeficiency Virus (HIV) testing among men in rural Burkina Faso. The study took place in 2009 in the Nouna Health District and adopted a triangulation mixed methods design. Nouna Health District, is located in north-western Burkina Faso. At the time of the study, the district had a population of approximately 311,000 distributed in 300 villages and included 31 first-line facilities, Centres de Santé et de Promotion Sociale (CSPS)and one district hospital. A sub-portion of the district has been part of a Health and Demographic Surveillance System (HDSS) for over 15 years. Following national policy, starting in 2006, all CSPS were equipped to offer HIV counseling and testing to pregnant women and their partners as the entry point to PMTCT services. Explicit efforts were made to address the need for couple counseling and testing, encouraging spouses to be tested together with their pregnant wives. In addition, providers were encouraged to offer testing to anyone requesting it and/or to anyone who presented with potential symptoms of infection. The quantitative component relied on data collected through a structured survey on a representative sample of 1130 households. The qualitative component relied on 38 in-depth interviews, with men purposely selected to represent variation in testing decision, age, and place of residence. Household survey data were analyzed using Stata 11 (Stata Corporation, Texas, USA). The outcome variable was defined as “having tested for HIV”.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
This study aimed to explore factors shaping the decision to undergo Human Immunodeficiency Virus (HIV) testing among men in rural Burkina Faso. The study took place in 2009 in the Nouna Health District and adopted a triangulation mixed methods design. Nouna Health District, is located in north-western Burkina Faso. At the time of the study, the district had a population of approximately 311,000 distributed in 300 villages and included 31 first-line facilities, Centres de Santé et de Promotion Sociale (CSPS)and one district hospital. A sub-portion of the district has been part of a Health and Demographic Surveillance System (HDSS) for over 15 years. Following national policy, starting in 2006, all CSPS were equipped to offer HIV counseling and testing to pregnant women and their partners as the entry point to PMTCT services. Explicit efforts were made to address the need for couple counseling and testing, encouraging spouses to be tested together with their pregnant wives. In addition, providers were encouraged to offer testing to anyone requesting it and/or to anyone who presented with potential symptoms of infection. The quantitative component relied on data collected through a structured survey on a representative sample of 1130 households. The qualitative component relied on 38 in-depth interviews, with men purposely selected to represent variation in testing decision, age, and place of residence. Household survey data were analyzed using Stata 11 (Stata Corporation, Texas, USA). The outcome variable was defined as “having tested for HIV”.
|
Medicine, Health and Life Sciences
|
Burkina Faso; HIV testing; men; mixed-methods; sub-Saharan Africa
|
doi:10.15139/S3/H3UJMQ
|
CBEHPP Filter Trial Data
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Long-format household-level data and long-format child-level data for the Community-Based Environmental Health Promotion Programme Filter Trial Study in Rwanda' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'WASH; water quality; Rwanda; diarrhea; child health'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'CBEHPP Filter Trial Data' Description:'Long-format household-level data and long-format child-level data for the Community-Based Environmental Health Promotion Programme Filter Trial Study in Rwanda' Subject:'Medicine, Health and Life Sciences; Social Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Long-format household-level data and long-format child-level data for the Community-Based Environmental Health Promotion Programme Filter Trial Study in Rwanda
|
Medicine, Health and Life Sciences
|
WASH; water quality; Rwanda; diarrhea; child health
|
doi:10.15139/S3/H3UJMQ
|
CBEHPP Filter Trial Data
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Long-format household-level data and long-format child-level data for the Community-Based Environmental Health Promotion Programme Filter Trial Study in Rwanda' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'WASH; water quality; Rwanda; diarrhea; child health'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'CBEHPP Filter Trial Data' Description:'Long-format household-level data and long-format child-level data for the Community-Based Environmental Health Promotion Programme Filter Trial Study in Rwanda' Subject:'Medicine, Health and Life Sciences; Social Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Long-format household-level data and long-format child-level data for the Community-Based Environmental Health Promotion Programme Filter Trial Study in Rwanda
|
Social Sciences
|
WASH; water quality; Rwanda; diarrhea; child health
|
doi:10.11588/data/7IWYPF
|
How to assess and interpret everyday life salivary cortisol measures: A tutorial on practical and statistical considerations [Research Data]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'The data and scripts accompany the following manuscript: 'How to assess and interpret everyday life salivary cortisol measures: A tutorial on practical and statistical considerations'. To use the data with the R scripts, we recommend downloading them in their original file format (.csv).' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Ambulatory assessment; Ecological momentary assessment; Multilevel modeling; Salivary cortisol; Stress'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'How to assess and interpret everyday life salivary cortisol measures: A tutorial on practical and statistical considerations [Research Data]' Description:'The data and scripts accompany the following manuscript: 'How to assess and interpret everyday life salivary cortisol measures: A tutorial on practical and statistical considerations'. To use the data with the R scripts, we recommend downloading them in their original file format (.csv).' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
The data and scripts accompany the following manuscript: 'How to assess and interpret everyday life salivary cortisol measures: A tutorial on practical and statistical considerations'. To use the data with the R scripts, we recommend downloading them in their original file format (.csv).
|
Medicine, Health and Life Sciences
|
Ambulatory assessment; Ecological momentary assessment; Multilevel modeling; Salivary cortisol; Stress
|
doi:10.11588/data/10092
|
HDAMM-predictor: prediction of progression in asymptomatic myeloma patients
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'The HDAMM-predictor is based on microarray gene expression and predicts the risk of progression from asymptomatic to symptomatic myeloma. It divides the patients in three groups, from low to high risk to progress. It was generated according to the method published by Rème et al. 2013. Gene expression profiles of 259 asymptomatic myeloma patients were used as trainingset.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Asymptomatic myeloma; Multiple myeloma; Prognosis; Progression; Risk prediction'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'HDAMM-predictor: prediction of progression in asymptomatic myeloma patients' Description:'The HDAMM-predictor is based on microarray gene expression and predicts the risk of progression from asymptomatic to symptomatic myeloma. It divides the patients in three groups, from low to high risk to progress. It was generated according to the method published by Rème et al. 2013. Gene expression profiles of 259 asymptomatic myeloma patients were used as trainingset.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
The HDAMM-predictor is based on microarray gene expression and predicts the risk of progression from asymptomatic to symptomatic myeloma. It divides the patients in three groups, from low to high risk to progress. It was generated according to the method published by Rème et al. 2013. Gene expression profiles of 259 asymptomatic myeloma patients were used as trainingset.
|
Medicine, Health and Life Sciences
|
Asymptomatic myeloma; Multiple myeloma; Prognosis; Progression; Risk prediction
|
doi:10.11588/data/10099
|
Promoting water consumption using behavioral economics insights [Dataset]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Mexico has one of the largest overweight and obesity epidemics in the world and as a response, several actions aiming to reduce the obesity epidemic have been already set in place. Some of these actions include a specific action program for schools looking to turn the scholar environments into supportive environments for the infants to make healthier food choices. The influence of the environment (the so-called “choice architecture”) on people’s perceptions and decisions is studied by economists with the aim of supporting individuals’ to make healthier decisions, using tools known as “nudges”. However, 'nudges' are not commonly integrated into anti-obesity strategies. We designed an intervention trying to find out whether such a small, liberty-preserving intervention could increase the effectiveness of a water-promotion campaign, when compared to the common approach of an educative talk. The intervention was developed in three schools in Mexico City and the State of Mexico. The body mass index, standardized by Z-scores, was used as the indicator of campaign success. Although – mainly due to problems within the sample and a yet too-short follow-up – our results do not show considerable differences between the approaches, they provide insights suggesting that including “nudges” into a health promoting campaign may indeed have a positive impact.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'behavioral economics; children; nudge; obesity; public health'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Promoting water consumption using behavioral economics insights [Dataset]' Description:'Mexico has one of the largest overweight and obesity epidemics in the world and as a response, several actions aiming to reduce the obesity epidemic have been already set in place. Some of these actions include a specific action program for schools looking to turn the scholar environments into supportive environments for the infants to make healthier food choices. The influence of the environment (the so-called “choice architecture”) on people’s perceptions and decisions is studied by economists with the aim of supporting individuals’ to make healthier decisions, using tools known as “nudges”. However, 'nudges' are not commonly integrated into anti-obesity strategies. We designed an intervention trying to find out whether such a small, liberty-preserving intervention could increase the effectiveness of a water-promotion campaign, when compared to the common approach of an educative talk. The intervention was developed in three schools in Mexico City and the State of Mexico. The body mass index, standardized by Z-scores, was used as the indicator of campaign success. Although – mainly due to problems within the sample and a yet too-short follow-up – our results do not show considerable differences between the approaches, they provide insights suggesting that including “nudges” into a health promoting campaign may indeed have a positive impact.' Subject:'Medicine, Health and Life Sciences; Social Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Mexico has one of the largest overweight and obesity epidemics in the world and as a response, several actions aiming to reduce the obesity epidemic have been already set in place. Some of these actions include a specific action program for schools looking to turn the scholar environments into supportive environments for the infants to make healthier food choices. The influence of the environment (the so-called “choice architecture”) on people’s perceptions and decisions is studied by economists with the aim of supporting individuals’ to make healthier decisions, using tools known as “nudges”. However, 'nudges' are not commonly integrated into anti-obesity strategies. We designed an intervention trying to find out whether such a small, liberty-preserving intervention could increase the effectiveness of a water-promotion campaign, when compared to the common approach of an educative talk. The intervention was developed in three schools in Mexico City and the State of Mexico. The body mass index, standardized by Z-scores, was used as the indicator of campaign success. Although – mainly due to problems within the sample and a yet too-short follow-up – our results do not show considerable differences between the approaches, they provide insights suggesting that including “nudges” into a health promoting campaign may indeed have a positive impact.
|
Medicine, Health and Life Sciences
|
behavioral economics; children; nudge; obesity; public health
|
doi:10.11588/data/10099
|
Promoting water consumption using behavioral economics insights [Dataset]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Mexico has one of the largest overweight and obesity epidemics in the world and as a response, several actions aiming to reduce the obesity epidemic have been already set in place. Some of these actions include a specific action program for schools looking to turn the scholar environments into supportive environments for the infants to make healthier food choices. The influence of the environment (the so-called “choice architecture”) on people’s perceptions and decisions is studied by economists with the aim of supporting individuals’ to make healthier decisions, using tools known as “nudges”. However, 'nudges' are not commonly integrated into anti-obesity strategies. We designed an intervention trying to find out whether such a small, liberty-preserving intervention could increase the effectiveness of a water-promotion campaign, when compared to the common approach of an educative talk. The intervention was developed in three schools in Mexico City and the State of Mexico. The body mass index, standardized by Z-scores, was used as the indicator of campaign success. Although – mainly due to problems within the sample and a yet too-short follow-up – our results do not show considerable differences between the approaches, they provide insights suggesting that including “nudges” into a health promoting campaign may indeed have a positive impact.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'behavioral economics; children; nudge; obesity; public health'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Promoting water consumption using behavioral economics insights [Dataset]' Description:'Mexico has one of the largest overweight and obesity epidemics in the world and as a response, several actions aiming to reduce the obesity epidemic have been already set in place. Some of these actions include a specific action program for schools looking to turn the scholar environments into supportive environments for the infants to make healthier food choices. The influence of the environment (the so-called “choice architecture”) on people’s perceptions and decisions is studied by economists with the aim of supporting individuals’ to make healthier decisions, using tools known as “nudges”. However, 'nudges' are not commonly integrated into anti-obesity strategies. We designed an intervention trying to find out whether such a small, liberty-preserving intervention could increase the effectiveness of a water-promotion campaign, when compared to the common approach of an educative talk. The intervention was developed in three schools in Mexico City and the State of Mexico. The body mass index, standardized by Z-scores, was used as the indicator of campaign success. Although – mainly due to problems within the sample and a yet too-short follow-up – our results do not show considerable differences between the approaches, they provide insights suggesting that including “nudges” into a health promoting campaign may indeed have a positive impact.' Subject:'Medicine, Health and Life Sciences; Social Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Mexico has one of the largest overweight and obesity epidemics in the world and as a response, several actions aiming to reduce the obesity epidemic have been already set in place. Some of these actions include a specific action program for schools looking to turn the scholar environments into supportive environments for the infants to make healthier food choices. The influence of the environment (the so-called “choice architecture”) on people’s perceptions and decisions is studied by economists with the aim of supporting individuals’ to make healthier decisions, using tools known as “nudges”. However, 'nudges' are not commonly integrated into anti-obesity strategies. We designed an intervention trying to find out whether such a small, liberty-preserving intervention could increase the effectiveness of a water-promotion campaign, when compared to the common approach of an educative talk. The intervention was developed in three schools in Mexico City and the State of Mexico. The body mass index, standardized by Z-scores, was used as the indicator of campaign success. Although – mainly due to problems within the sample and a yet too-short follow-up – our results do not show considerable differences between the approaches, they provide insights suggesting that including “nudges” into a health promoting campaign may indeed have a positive impact.
|
Social Sciences
|
behavioral economics; children; nudge; obesity; public health
|
doi:10.11588/data/3NKHAY
|
Dual kinetic and structural role for the surface in guiding SAS-6 self-assembly to direct centriole architecture [Data]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'This dataset contains input structures and parameters for coarse-grained molecular dynamics simulation of SAS-6 protein oligomers as well as post-processing files and analysis scripts. Abstract of related publication:Discovering mechanisms governing organelle assembly is a fundamental pursuit in the life sciences. The centriole is an evolutionarily conserved organelle with a signature 9-fold symmetrical chiral arrangement of microtubules imparted onto the cilium it templates. The first structure in nascent centrioles is a cartwheel, which comprises stacked 9-fold symmetrical SAS-6 ring polymers and emerging orthogonal to a surface surrounding resident centrioles. The mechanisms through which SAS-6 polymerization ensures centriole organelle architecture remain elusive. We deployed photothermally-actuated off-resonance tapping high-speed atomic force microscopy (PORT-HS-AFM) to decipher surface SAS-6 self-assembly mechanisms. We discovered that the surface shifts the reaction equilibrium by ~104 compared to solution. Moreover, coarse-grained molecular dynamics simulations and PORT-HS-AFM revealed that the surface converts the inherently helical propensity of SAS-6 polymers into 9-fold rings with residual asymmetry, which may guide ring stacking and impart chiral features to centrioles and cilia. Overall, our work reveals fundamental design principles governing centriole assembly.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'centriole assembly; coarse-graining; Martini force field; MD simulation; SAS-6'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Dual kinetic and structural role for the surface in guiding SAS-6 self-assembly to direct centriole architecture [Data]' Description:'This dataset contains input structures and parameters for coarse-grained molecular dynamics simulation of SAS-6 protein oligomers as well as post-processing files and analysis scripts. Abstract of related publication:Discovering mechanisms governing organelle assembly is a fundamental pursuit in the life sciences. The centriole is an evolutionarily conserved organelle with a signature 9-fold symmetrical chiral arrangement of microtubules imparted onto the cilium it templates. The first structure in nascent centrioles is a cartwheel, which comprises stacked 9-fold symmetrical SAS-6 ring polymers and emerging orthogonal to a surface surrounding resident centrioles. The mechanisms through which SAS-6 polymerization ensures centriole organelle architecture remain elusive. We deployed photothermally-actuated off-resonance tapping high-speed atomic force microscopy (PORT-HS-AFM) to decipher surface SAS-6 self-assembly mechanisms. We discovered that the surface shifts the reaction equilibrium by ~104 compared to solution. Moreover, coarse-grained molecular dynamics simulations and PORT-HS-AFM revealed that the surface converts the inherently helical propensity of SAS-6 polymers into 9-fold rings with residual asymmetry, which may guide ring stacking and impart chiral features to centrioles and cilia. Overall, our work reveals fundamental design principles governing centriole assembly.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
This dataset contains input structures and parameters for coarse-grained molecular dynamics simulation of SAS-6 protein oligomers as well as post-processing files and analysis scripts. Abstract of related publication:Discovering mechanisms governing organelle assembly is a fundamental pursuit in the life sciences. The centriole is an evolutionarily conserved organelle with a signature 9-fold symmetrical chiral arrangement of microtubules imparted onto the cilium it templates. The first structure in nascent centrioles is a cartwheel, which comprises stacked 9-fold symmetrical SAS-6 ring polymers and emerging orthogonal to a surface surrounding resident centrioles. The mechanisms through which SAS-6 polymerization ensures centriole organelle architecture remain elusive. We deployed photothermally-actuated off-resonance tapping high-speed atomic force microscopy (PORT-HS-AFM) to decipher surface SAS-6 self-assembly mechanisms. We discovered that the surface shifts the reaction equilibrium by ~104 compared to solution. Moreover, coarse-grained molecular dynamics simulations and PORT-HS-AFM revealed that the surface converts the inherently helical propensity of SAS-6 polymers into 9-fold rings with residual asymmetry, which may guide ring stacking and impart chiral features to centrioles and cilia. Overall, our work reveals fundamental design principles governing centriole assembly.
|
Medicine, Health and Life Sciences
|
centriole assembly; coarse-graining; Martini force field; MD simulation; SAS-6
|
doi:10.11588/data/5JCEVW
|
Physicians’ Attitudes towards Secondary Use of Clinical Data for Biomedical Research Purposes. Results of a Quantitative Survey. [Research Data]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'This is the research data from the publication 'Physicians' Attitudes toward Secondary Use of Clinical Data for Biomedical Research Purposes. Results of a Quantitative Survey.' The research data includes the questionnaire, the data set used, and a description of the data preparation.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'clinical data; data access; data sharing; health data; physician attitudes; physician-scientists; secondary use'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Physicians’ Attitudes towards Secondary Use of Clinical Data for Biomedical Research Purposes. Results of a Quantitative Survey. [Research Data]' Description:'This is the research data from the publication 'Physicians' Attitudes toward Secondary Use of Clinical Data for Biomedical Research Purposes. Results of a Quantitative Survey.' The research data includes the questionnaire, the data set used, and a description of the data preparation.' Subject:'Medicine, Health and Life Sciences; Social Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
This is the research data from the publication 'Physicians' Attitudes toward Secondary Use of Clinical Data for Biomedical Research Purposes. Results of a Quantitative Survey.' The research data includes the questionnaire, the data set used, and a description of the data preparation.
|
Medicine, Health and Life Sciences
|
clinical data; data access; data sharing; health data; physician attitudes; physician-scientists; secondary use
|
doi:10.11588/data/5JCEVW
|
Physicians’ Attitudes towards Secondary Use of Clinical Data for Biomedical Research Purposes. Results of a Quantitative Survey. [Research Data]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'This is the research data from the publication 'Physicians' Attitudes toward Secondary Use of Clinical Data for Biomedical Research Purposes. Results of a Quantitative Survey.' The research data includes the questionnaire, the data set used, and a description of the data preparation.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'clinical data; data access; data sharing; health data; physician attitudes; physician-scientists; secondary use'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Physicians’ Attitudes towards Secondary Use of Clinical Data for Biomedical Research Purposes. Results of a Quantitative Survey. [Research Data]' Description:'This is the research data from the publication 'Physicians' Attitudes toward Secondary Use of Clinical Data for Biomedical Research Purposes. Results of a Quantitative Survey.' The research data includes the questionnaire, the data set used, and a description of the data preparation.' Subject:'Medicine, Health and Life Sciences; Social Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
This is the research data from the publication 'Physicians' Attitudes toward Secondary Use of Clinical Data for Biomedical Research Purposes. Results of a Quantitative Survey.' The research data includes the questionnaire, the data set used, and a description of the data preparation.
|
Social Sciences
|
clinical data; data access; data sharing; health data; physician attitudes; physician-scientists; secondary use
|
doi:10.11588/data/5RSAM3
|
DCE-MRI of the human kidney using BLADE: A feasibility study in healthy volunteers [Dataset]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'To evaluate the degree of motion compensation in the kidney using two different sampling methods, each in their optimized settings: A BLADE k-space acquisition technique and a routinely used kidney perfusion acquisition scheme (TurboFLASH).Dynamic contrast enhanced magnetic resonance examinations were performed in 16 healthy volunteers on a 3 Tesla MR-system with two parameterizations of the BLADE sequence and the standard reference acquisition scheme. Signal intensity enhanced time curves were analyzed with a mathematical model and a widely published separable compartment model on cortex regions to assess robustness versus motion artifacts' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'BLADE; DCE-MRI; Motion Correction; Perfusion'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'DCE-MRI of the human kidney using BLADE: A feasibility study in healthy volunteers [Dataset]' Description:'To evaluate the degree of motion compensation in the kidney using two different sampling methods, each in their optimized settings: A BLADE k-space acquisition technique and a routinely used kidney perfusion acquisition scheme (TurboFLASH).Dynamic contrast enhanced magnetic resonance examinations were performed in 16 healthy volunteers on a 3 Tesla MR-system with two parameterizations of the BLADE sequence and the standard reference acquisition scheme. Signal intensity enhanced time curves were analyzed with a mathematical model and a widely published separable compartment model on cortex regions to assess robustness versus motion artifacts' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
To evaluate the degree of motion compensation in the kidney using two different sampling methods, each in their optimized settings: A BLADE k-space acquisition technique and a routinely used kidney perfusion acquisition scheme (TurboFLASH).Dynamic contrast enhanced magnetic resonance examinations were performed in 16 healthy volunteers on a 3 Tesla MR-system with two parameterizations of the BLADE sequence and the standard reference acquisition scheme. Signal intensity enhanced time curves were analyzed with a mathematical model and a widely published separable compartment model on cortex regions to assess robustness versus motion artifacts
|
Medicine, Health and Life Sciences
|
BLADE; DCE-MRI; Motion Correction; Perfusion
|
doi:10.11588/data/7NRFYC
|
Synthesis of CT images from digital body phantoms using CycleGAN [dataset]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'The potential of medical image analysis with neural networks is limited by the restricted availability of extensive data sets. The incorporation of synthetic training data is one approach to bypass this shortcoming, as synthetic data offer accurate annotations and unlimited data size. We evaluated eleven CycleGAN for the synthesis of computed tomography (CT) images based on XCAT body phantoms.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'CT synthesis; CycleGAN; Generative Adversial Networks; physical modeling; simulation based deep learning'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Synthesis of CT images from digital body phantoms using CycleGAN [dataset]' Description:'The potential of medical image analysis with neural networks is limited by the restricted availability of extensive data sets. The incorporation of synthetic training data is one approach to bypass this shortcoming, as synthetic data offer accurate annotations and unlimited data size. We evaluated eleven CycleGAN for the synthesis of computed tomography (CT) images based on XCAT body phantoms.' Subject:'Computer and Information Science; Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
The potential of medical image analysis with neural networks is limited by the restricted availability of extensive data sets. The incorporation of synthetic training data is one approach to bypass this shortcoming, as synthetic data offer accurate annotations and unlimited data size. We evaluated eleven CycleGAN for the synthesis of computed tomography (CT) images based on XCAT body phantoms.
|
Computer and Information Science
|
CT synthesis; CycleGAN; Generative Adversial Networks; physical modeling; simulation based deep learning
|
doi:10.11588/data/7NRFYC
|
Synthesis of CT images from digital body phantoms using CycleGAN [dataset]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'The potential of medical image analysis with neural networks is limited by the restricted availability of extensive data sets. The incorporation of synthetic training data is one approach to bypass this shortcoming, as synthetic data offer accurate annotations and unlimited data size. We evaluated eleven CycleGAN for the synthesis of computed tomography (CT) images based on XCAT body phantoms.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'CT synthesis; CycleGAN; Generative Adversial Networks; physical modeling; simulation based deep learning'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Synthesis of CT images from digital body phantoms using CycleGAN [dataset]' Description:'The potential of medical image analysis with neural networks is limited by the restricted availability of extensive data sets. The incorporation of synthetic training data is one approach to bypass this shortcoming, as synthetic data offer accurate annotations and unlimited data size. We evaluated eleven CycleGAN for the synthesis of computed tomography (CT) images based on XCAT body phantoms.' Subject:'Computer and Information Science; Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
The potential of medical image analysis with neural networks is limited by the restricted availability of extensive data sets. The incorporation of synthetic training data is one approach to bypass this shortcoming, as synthetic data offer accurate annotations and unlimited data size. We evaluated eleven CycleGAN for the synthesis of computed tomography (CT) images based on XCAT body phantoms.
|
Medicine, Health and Life Sciences
|
CT synthesis; CycleGAN; Generative Adversial Networks; physical modeling; simulation based deep learning
|
doi:10.11588/data/8LKEZF
|
Normalization of HE-Stained Histological Images using Cycle Consistent Generative Adversarial Networks [Dataset]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Here we provide the data sets supporting the experiments in our publication Normalization of HE-Stained Histological Images using Cycle Consistent Generative Adversarial Networks, which were collected at the Institute of Pathology, Medical Faculty Mannheim, Heidelberg University. The HE-Staining Variation (HEV) data set offers serial sections of a follicular thyroid carcinoma, stained with different HE-staining protocols (including name of [stainVariant]):stained with HE with the standard protocol of the Institute of Pathology, Mannheim (HE)stained too long with HE (longHE)stained too short with HE (shortHE)stained only with Hematoxylin (onlyH)stained only with Eosin (onlyE)stained too long with Hematoxylin (longH)stained too long with Eosin (longE)stained too short with Hematoxylin (shortH)stained too short with Eosin (shortE)We provided the original whole-slide-images (WSI) in the folder HEV_wsi.zip for each stain-variant.In addition, for the stain-variants 1-5 we provide patches (n ~40,000 for each set) of size 256x256 pixels and split them into 60% train (train_[stainVariant].zip) and 40% test (test_[stainVariant].zip) sets . Patches from our TumorLymphnode data set for image classification are provided inside tumorLymphnode_patches.zip. It contains ~3,600 patches of size 165x165 pixels for each class normal lymph nodes (normal) and carcinoma infiltration (tumor).The code for our models is available at Gitlab.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Stain Normalization'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Normalization of HE-Stained Histological Images using Cycle Consistent Generative Adversarial Networks [Dataset]' Description:'Here we provide the data sets supporting the experiments in our publication Normalization of HE-Stained Histological Images using Cycle Consistent Generative Adversarial Networks, which were collected at the Institute of Pathology, Medical Faculty Mannheim, Heidelberg University. The HE-Staining Variation (HEV) data set offers serial sections of a follicular thyroid carcinoma, stained with different HE-staining protocols (including name of [stainVariant]):stained with HE with the standard protocol of the Institute of Pathology, Mannheim (HE)stained too long with HE (longHE)stained too short with HE (shortHE)stained only with Hematoxylin (onlyH)stained only with Eosin (onlyE)stained too long with Hematoxylin (longH)stained too long with Eosin (longE)stained too short with Hematoxylin (shortH)stained too short with Eosin (shortE)We provided the original whole-slide-images (WSI) in the folder HEV_wsi.zip for each stain-variant.In addition, for the stain-variants 1-5 we provide patches (n ~40,000 for each set) of size 256x256 pixels and split them into 60% train (train_[stainVariant].zip) and 40% test (test_[stainVariant].zip) sets . Patches from our TumorLymphnode data set for image classification are provided inside tumorLymphnode_patches.zip. It contains ~3,600 patches of size 165x165 pixels for each class normal lymph nodes (normal) and carcinoma infiltration (tumor).The code for our models is available at Gitlab.' Subject:'Computer and Information Science; Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Here we provide the data sets supporting the experiments in our publication Normalization of HE-Stained Histological Images using Cycle Consistent Generative Adversarial Networks, which were collected at the Institute of Pathology, Medical Faculty Mannheim, Heidelberg University. The HE-Staining Variation (HEV) data set offers serial sections of a follicular thyroid carcinoma, stained with different HE-staining protocols (including name of [stainVariant]):stained with HE with the standard protocol of the Institute of Pathology, Mannheim (HE)stained too long with HE (longHE)stained too short with HE (shortHE)stained only with Hematoxylin (onlyH)stained only with Eosin (onlyE)stained too long with Hematoxylin (longH)stained too long with Eosin (longE)stained too short with Hematoxylin (shortH)stained too short with Eosin (shortE)We provided the original whole-slide-images (WSI) in the folder HEV_wsi.zip for each stain-variant.In addition, for the stain-variants 1-5 we provide patches (n ~40,000 for each set) of size 256x256 pixels and split them into 60% train (train_[stainVariant].zip) and 40% test (test_[stainVariant].zip) sets . Patches from our TumorLymphnode data set for image classification are provided inside tumorLymphnode_patches.zip. It contains ~3,600 patches of size 165x165 pixels for each class normal lymph nodes (normal) and carcinoma infiltration (tumor).The code for our models is available at Gitlab.
|
Computer and Information Science
|
Stain Normalization
|
doi:10.11588/data/8LKEZF
|
Normalization of HE-Stained Histological Images using Cycle Consistent Generative Adversarial Networks [Dataset]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Here we provide the data sets supporting the experiments in our publication Normalization of HE-Stained Histological Images using Cycle Consistent Generative Adversarial Networks, which were collected at the Institute of Pathology, Medical Faculty Mannheim, Heidelberg University. The HE-Staining Variation (HEV) data set offers serial sections of a follicular thyroid carcinoma, stained with different HE-staining protocols (including name of [stainVariant]):stained with HE with the standard protocol of the Institute of Pathology, Mannheim (HE)stained too long with HE (longHE)stained too short with HE (shortHE)stained only with Hematoxylin (onlyH)stained only with Eosin (onlyE)stained too long with Hematoxylin (longH)stained too long with Eosin (longE)stained too short with Hematoxylin (shortH)stained too short with Eosin (shortE)We provided the original whole-slide-images (WSI) in the folder HEV_wsi.zip for each stain-variant.In addition, for the stain-variants 1-5 we provide patches (n ~40,000 for each set) of size 256x256 pixels and split them into 60% train (train_[stainVariant].zip) and 40% test (test_[stainVariant].zip) sets . Patches from our TumorLymphnode data set for image classification are provided inside tumorLymphnode_patches.zip. It contains ~3,600 patches of size 165x165 pixels for each class normal lymph nodes (normal) and carcinoma infiltration (tumor).The code for our models is available at Gitlab.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Stain Normalization'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Normalization of HE-Stained Histological Images using Cycle Consistent Generative Adversarial Networks [Dataset]' Description:'Here we provide the data sets supporting the experiments in our publication Normalization of HE-Stained Histological Images using Cycle Consistent Generative Adversarial Networks, which were collected at the Institute of Pathology, Medical Faculty Mannheim, Heidelberg University. The HE-Staining Variation (HEV) data set offers serial sections of a follicular thyroid carcinoma, stained with different HE-staining protocols (including name of [stainVariant]):stained with HE with the standard protocol of the Institute of Pathology, Mannheim (HE)stained too long with HE (longHE)stained too short with HE (shortHE)stained only with Hematoxylin (onlyH)stained only with Eosin (onlyE)stained too long with Hematoxylin (longH)stained too long with Eosin (longE)stained too short with Hematoxylin (shortH)stained too short with Eosin (shortE)We provided the original whole-slide-images (WSI) in the folder HEV_wsi.zip for each stain-variant.In addition, for the stain-variants 1-5 we provide patches (n ~40,000 for each set) of size 256x256 pixels and split them into 60% train (train_[stainVariant].zip) and 40% test (test_[stainVariant].zip) sets . Patches from our TumorLymphnode data set for image classification are provided inside tumorLymphnode_patches.zip. It contains ~3,600 patches of size 165x165 pixels for each class normal lymph nodes (normal) and carcinoma infiltration (tumor).The code for our models is available at Gitlab.' Subject:'Computer and Information Science; Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Here we provide the data sets supporting the experiments in our publication Normalization of HE-Stained Histological Images using Cycle Consistent Generative Adversarial Networks, which were collected at the Institute of Pathology, Medical Faculty Mannheim, Heidelberg University. The HE-Staining Variation (HEV) data set offers serial sections of a follicular thyroid carcinoma, stained with different HE-staining protocols (including name of [stainVariant]):stained with HE with the standard protocol of the Institute of Pathology, Mannheim (HE)stained too long with HE (longHE)stained too short with HE (shortHE)stained only with Hematoxylin (onlyH)stained only with Eosin (onlyE)stained too long with Hematoxylin (longH)stained too long with Eosin (longE)stained too short with Hematoxylin (shortH)stained too short with Eosin (shortE)We provided the original whole-slide-images (WSI) in the folder HEV_wsi.zip for each stain-variant.In addition, for the stain-variants 1-5 we provide patches (n ~40,000 for each set) of size 256x256 pixels and split them into 60% train (train_[stainVariant].zip) and 40% test (test_[stainVariant].zip) sets . Patches from our TumorLymphnode data set for image classification are provided inside tumorLymphnode_patches.zip. It contains ~3,600 patches of size 165x165 pixels for each class normal lymph nodes (normal) and carcinoma infiltration (tumor).The code for our models is available at Gitlab.
|
Medicine, Health and Life Sciences
|
Stain Normalization
|
doi:10.11588/data/AOSUS8
|
Fish primary embryonic pluripotent cells assemble into retinal tissue mirroring in vivo early eye development - in vivo imaging of OV formation
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Development of a functional retina is accompanied by several morphological events transitions that ultimately result in the formation of a functional retina. One of them is the formation of the OV. When fish-derived organoids were generated with reduced cell-seeding density by 50%, the organoids formed individual domains reminiscent of the forming optic vesicle in vivo. To address the mode of OV formation in fish organoids, we employed live imaging of Rx3::H2B-GFP-derived organoids from day 1 to day 2 of development. This dataset is a raw data from live imaging of Rx3::H2B-GFP-derived organoids from day 1 to day 2 of development performed on the 16× detection MuVi SPIM Multiview light-sheet microscope (Luxendo Light-sheet, Bruker Corporation).' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'in vivo imaging; light-sheet microscopy; medaka fish; organoid; retina'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Fish primary embryonic pluripotent cells assemble into retinal tissue mirroring in vivo early eye development - in vivo imaging of OV formation' Description:'Development of a functional retina is accompanied by several morphological events transitions that ultimately result in the formation of a functional retina. One of them is the formation of the OV. When fish-derived organoids were generated with reduced cell-seeding density by 50%, the organoids formed individual domains reminiscent of the forming optic vesicle in vivo. To address the mode of OV formation in fish organoids, we employed live imaging of Rx3::H2B-GFP-derived organoids from day 1 to day 2 of development. This dataset is a raw data from live imaging of Rx3::H2B-GFP-derived organoids from day 1 to day 2 of development performed on the 16× detection MuVi SPIM Multiview light-sheet microscope (Luxendo Light-sheet, Bruker Corporation).' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Development of a functional retina is accompanied by several morphological events transitions that ultimately result in the formation of a functional retina. One of them is the formation of the OV. When fish-derived organoids were generated with reduced cell-seeding density by 50%, the organoids formed individual domains reminiscent of the forming optic vesicle in vivo. To address the mode of OV formation in fish organoids, we employed live imaging of Rx3::H2B-GFP-derived organoids from day 1 to day 2 of development. This dataset is a raw data from live imaging of Rx3::H2B-GFP-derived organoids from day 1 to day 2 of development performed on the 16× detection MuVi SPIM Multiview light-sheet microscope (Luxendo Light-sheet, Bruker Corporation).
|
Medicine, Health and Life Sciences
|
in vivo imaging; light-sheet microscopy; medaka fish; organoid; retina
|
doi:10.11588/data/ARWJHB
|
Mittelalterliche Pflanzenreste von der Marktstätte und Brotlaube in Konstanz [Dataset]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'During excavations in medieval Konstanz very many samples were taken for archaeobotanical analyses. Samples could be dated to different time layers from High to Late Middle Ages. Spelt, millet and oats were probably the most important cereals. But also flax, hemp, figs and spices were recorded.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Archaeobotany; Konstanz; Middle Ages'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Mittelalterliche Pflanzenreste von der Marktstätte und Brotlaube in Konstanz [Dataset]' Description:'During excavations in medieval Konstanz very many samples were taken for archaeobotanical analyses. Samples could be dated to different time layers from High to Late Middle Ages. Spelt, millet and oats were probably the most important cereals. But also flax, hemp, figs and spices were recorded.' Subject:'Arts and Humanities; Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
During excavations in medieval Konstanz very many samples were taken for archaeobotanical analyses. Samples could be dated to different time layers from High to Late Middle Ages. Spelt, millet and oats were probably the most important cereals. But also flax, hemp, figs and spices were recorded.
|
Arts and Humanities
|
Archaeobotany; Konstanz; Middle Ages
|
doi:10.11588/data/ARWJHB
|
Mittelalterliche Pflanzenreste von der Marktstätte und Brotlaube in Konstanz [Dataset]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'During excavations in medieval Konstanz very many samples were taken for archaeobotanical analyses. Samples could be dated to different time layers from High to Late Middle Ages. Spelt, millet and oats were probably the most important cereals. But also flax, hemp, figs and spices were recorded.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Archaeobotany; Konstanz; Middle Ages'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Mittelalterliche Pflanzenreste von der Marktstätte und Brotlaube in Konstanz [Dataset]' Description:'During excavations in medieval Konstanz very many samples were taken for archaeobotanical analyses. Samples could be dated to different time layers from High to Late Middle Ages. Spelt, millet and oats were probably the most important cereals. But also flax, hemp, figs and spices were recorded.' Subject:'Arts and Humanities; Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
During excavations in medieval Konstanz very many samples were taken for archaeobotanical analyses. Samples could be dated to different time layers from High to Late Middle Ages. Spelt, millet and oats were probably the most important cereals. But also flax, hemp, figs and spices were recorded.
|
Medicine, Health and Life Sciences
|
Archaeobotany; Konstanz; Middle Ages
|
doi:10.11588/data/ARWJHB
|
Mittelalterliche Pflanzenreste von der Marktstätte und Brotlaube in Konstanz [Dataset]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'During excavations in medieval Konstanz very many samples were taken for archaeobotanical analyses. Samples could be dated to different time layers from High to Late Middle Ages. Spelt, millet and oats were probably the most important cereals. But also flax, hemp, figs and spices were recorded.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Archaeobotany; Konstanz; Middle Ages'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Mittelalterliche Pflanzenreste von der Marktstätte und Brotlaube in Konstanz [Dataset]' Description:'During excavations in medieval Konstanz very many samples were taken for archaeobotanical analyses. Samples could be dated to different time layers from High to Late Middle Ages. Spelt, millet and oats were probably the most important cereals. But also flax, hemp, figs and spices were recorded.' Subject:'Arts and Humanities; Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
During excavations in medieval Konstanz very many samples were taken for archaeobotanical analyses. Samples could be dated to different time layers from High to Late Middle Ages. Spelt, millet and oats were probably the most important cereals. But also flax, hemp, figs and spices were recorded.
|
Arts and Humanities
|
Archaeobotany; Konstanz; Middle Ages
|
doi:10.11588/data/ARWJHB
|
Mittelalterliche Pflanzenreste von der Marktstätte und Brotlaube in Konstanz [Dataset]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'During excavations in medieval Konstanz very many samples were taken for archaeobotanical analyses. Samples could be dated to different time layers from High to Late Middle Ages. Spelt, millet and oats were probably the most important cereals. But also flax, hemp, figs and spices were recorded.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Archaeobotany; Konstanz; Middle Ages'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Mittelalterliche Pflanzenreste von der Marktstätte und Brotlaube in Konstanz [Dataset]' Description:'During excavations in medieval Konstanz very many samples were taken for archaeobotanical analyses. Samples could be dated to different time layers from High to Late Middle Ages. Spelt, millet and oats were probably the most important cereals. But also flax, hemp, figs and spices were recorded.' Subject:'Arts and Humanities; Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
During excavations in medieval Konstanz very many samples were taken for archaeobotanical analyses. Samples could be dated to different time layers from High to Late Middle Ages. Spelt, millet and oats were probably the most important cereals. But also flax, hemp, figs and spices were recorded.
|
Medicine, Health and Life Sciences
|
Archaeobotany; Konstanz; Middle Ages
|
doi:10.11588/data/BQTQUN
|
Intrinsically disordered region of talin’s FERM domain functions as an initial PIP2 recognition site [research data]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Focal adhesions (FAs) mediate the interaction of the cytoskeleton with the extracellular matrix (ECM) in a highly dynamic fashion. talin is a central regulator, adaptor protein and mechano-sensor of focal adhesion complexes. For recruitment and firm attachment at FAs, talin’s N-terminal FERM domain binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-enriched membranes. A newly published autoinhibitory structure of talin-1, where the known PIP2 interaction sites are covered up, lead us to hypothesize that a hitherto less examined loop insertion of the FERM domain acts as an additional and initial site of contact. We evaluated direct interactions of talin-1 with a PIP2 membrane by means of atomistic molecular dynamics (MD) simulations. We show that this unstructured, 33-residue-long loop strongly interacts with PIP2 and can facilitate further membrane contacts, including the canonical PIP2 interactions, by serving as a flexible membrane anchor. Under force as present at FAs, the extensible FERM loop ensures talin to maintain membrane contacts when pulled away from the membrane by up to 7 nm. We identify key basic residues of the anchor mediating the highly dynamic talin-membrane interaction. Our results put forward an intrinsically disordered loop as a key and highly adaptable PIP2 recognition site of talin and potentially other PIP2-binding mechano-proteins.This dataset contains setup scripts, molecular dynamics parameters, input files and derived data from the molecular dynamics simulations of this paper available at https://hits-mbm-dev.github.io/paper-talin-loop/.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'molecular dynamics; PIP2; talin-1'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Intrinsically disordered region of talin’s FERM domain functions as an initial PIP2 recognition site [research data]' Description:'Focal adhesions (FAs) mediate the interaction of the cytoskeleton with the extracellular matrix (ECM) in a highly dynamic fashion. talin is a central regulator, adaptor protein and mechano-sensor of focal adhesion complexes. For recruitment and firm attachment at FAs, talin’s N-terminal FERM domain binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-enriched membranes. A newly published autoinhibitory structure of talin-1, where the known PIP2 interaction sites are covered up, lead us to hypothesize that a hitherto less examined loop insertion of the FERM domain acts as an additional and initial site of contact. We evaluated direct interactions of talin-1 with a PIP2 membrane by means of atomistic molecular dynamics (MD) simulations. We show that this unstructured, 33-residue-long loop strongly interacts with PIP2 and can facilitate further membrane contacts, including the canonical PIP2 interactions, by serving as a flexible membrane anchor. Under force as present at FAs, the extensible FERM loop ensures talin to maintain membrane contacts when pulled away from the membrane by up to 7 nm. We identify key basic residues of the anchor mediating the highly dynamic talin-membrane interaction. Our results put forward an intrinsically disordered loop as a key and highly adaptable PIP2 recognition site of talin and potentially other PIP2-binding mechano-proteins.This dataset contains setup scripts, molecular dynamics parameters, input files and derived data from the molecular dynamics simulations of this paper available at https://hits-mbm-dev.github.io/paper-talin-loop/.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Focal adhesions (FAs) mediate the interaction of the cytoskeleton with the extracellular matrix (ECM) in a highly dynamic fashion. talin is a central regulator, adaptor protein and mechano-sensor of focal adhesion complexes. For recruitment and firm attachment at FAs, talin’s N-terminal FERM domain binds to phosphatidylinositol 4,5-bisphosphate (PIP2)-enriched membranes. A newly published autoinhibitory structure of talin-1, where the known PIP2 interaction sites are covered up, lead us to hypothesize that a hitherto less examined loop insertion of the FERM domain acts as an additional and initial site of contact. We evaluated direct interactions of talin-1 with a PIP2 membrane by means of atomistic molecular dynamics (MD) simulations. We show that this unstructured, 33-residue-long loop strongly interacts with PIP2 and can facilitate further membrane contacts, including the canonical PIP2 interactions, by serving as a flexible membrane anchor. Under force as present at FAs, the extensible FERM loop ensures talin to maintain membrane contacts when pulled away from the membrane by up to 7 nm. We identify key basic residues of the anchor mediating the highly dynamic talin-membrane interaction. Our results put forward an intrinsically disordered loop as a key and highly adaptable PIP2 recognition site of talin and potentially other PIP2-binding mechano-proteins.This dataset contains setup scripts, molecular dynamics parameters, input files and derived data from the molecular dynamics simulations of this paper available at https://hits-mbm-dev.github.io/paper-talin-loop/.
|
Medicine, Health and Life Sciences
|
molecular dynamics; PIP2; talin-1
|
doi:10.11588/data/D0ACC0
|
Evaluation of the accuracy, exclusivity, limit-of-detection and ease-of-use of the LumiraDx SARS-CoV-2 test - A rapid, antigen-detecting point-of-care tool for the diagnosis of SARS-CoV-2 [Research Data]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'This repository includes data from a prospective, multi-centre diagnostic accuracy study. The study was conducted at two sites in Germany, Heidelberg and Berlin. Following routine testing with reverse-transcriptase polymerase chain reaction (RT-PCR), a second study-exclusive swab was performed for Ag-RDT testing. Routine swabs were nasopharyngeal (NP) or combined NP/oropharyngeal (OP) whereas the study-exclusive swabs were NP. To evaluate performance, sensitivity and specificity were assessed overall and in predefined sub analyses accordingly to viral load, days of symptoms and symptoms. In addition, further data from the participants were collected during interviews' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'antigen-detecting rapid tests; Covid-19; Diagnostics; SARS-CoV-2'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Evaluation of the accuracy, exclusivity, limit-of-detection and ease-of-use of the LumiraDx SARS-CoV-2 test - A rapid, antigen-detecting point-of-care tool for the diagnosis of SARS-CoV-2 [Research Data]' Description:'This repository includes data from a prospective, multi-centre diagnostic accuracy study. The study was conducted at two sites in Germany, Heidelberg and Berlin. Following routine testing with reverse-transcriptase polymerase chain reaction (RT-PCR), a second study-exclusive swab was performed for Ag-RDT testing. Routine swabs were nasopharyngeal (NP) or combined NP/oropharyngeal (OP) whereas the study-exclusive swabs were NP. To evaluate performance, sensitivity and specificity were assessed overall and in predefined sub analyses accordingly to viral load, days of symptoms and symptoms. In addition, further data from the participants were collected during interviews' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
This repository includes data from a prospective, multi-centre diagnostic accuracy study. The study was conducted at two sites in Germany, Heidelberg and Berlin. Following routine testing with reverse-transcriptase polymerase chain reaction (RT-PCR), a second study-exclusive swab was performed for Ag-RDT testing. Routine swabs were nasopharyngeal (NP) or combined NP/oropharyngeal (OP) whereas the study-exclusive swabs were NP. To evaluate performance, sensitivity and specificity were assessed overall and in predefined sub analyses accordingly to viral load, days of symptoms and symptoms. In addition, further data from the participants were collected during interviews
|
Medicine, Health and Life Sciences
|
antigen-detecting rapid tests; Covid-19; Diagnostics; SARS-CoV-2
|
doi:10.11588/data/DNOSZG
|
Monosynaptic trans-collicular pathways for sensory-motor integration in the whisker system [Research Data]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'This dataset contains electrophysiological spike time data and figure data for anatomical quantifications reported in Martín-Cortecero et al. Monosynaptic trans-collicular pathways for sensory-motor integration in the whisker system(2023).Abstract: The superior colliculus (SC), a conserved midbrain-node with extensive long-range connectivity throughout the brain, is a key structure for innate behaviors. Descending cortical pathways are increasingly recognized as central control points for SC-mediated behaviors, but how cortico-collicular pathways coordinate SC activity at the cellular level is poorly understood. Moreover, despite the known role of the SC as a multisensory integrator, the involvement of the SC in the somatosensory system is largely unexplored in comparison to its involvement in the visual and auditory systems. Here, we mapped the input-output properties of the whisker-sensitive region of the SC in mice with transsynaptic and intersectional tracing tools and in vivo electrophysiology. The results reveal a novel trans-collicular connectivity motif by which neurons in motor- and somatosensory cortices impinge onto the brainstem-SC-brainstem sensory-motor arc and onto SC-midbrain output pathways via only one synapse in the SC. Intersectional approaches and optogenetically assisted connectivity quantifications in vivo reveal convergence of motor and somatosensory cortical input on individual SC neurons, providing a new framework for sensory-motor integration in the SC. More than a third of the cortical recipient neurons in the whisker SC are GABAergic neurons, which accommodate hitherto unknown GABAergic projection neurons, targeting thalamic nuclei and the zona incerta. These results pinpoint a whisker region in the SC of mice as a node for the integration of somatosensory and motor cortical signals via parallel excitatory and inhibitory trans-collicular pathways which link cortical and subcortical whisker circuits for somato-motor integration.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'optogenetics; sensory circuits; sensory-motor convergence; spike time data; superior colliculus; whisker system'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Monosynaptic trans-collicular pathways for sensory-motor integration in the whisker system [Research Data]' Description:'This dataset contains electrophysiological spike time data and figure data for anatomical quantifications reported in Martín-Cortecero et al. Monosynaptic trans-collicular pathways for sensory-motor integration in the whisker system(2023).Abstract: The superior colliculus (SC), a conserved midbrain-node with extensive long-range connectivity throughout the brain, is a key structure for innate behaviors. Descending cortical pathways are increasingly recognized as central control points for SC-mediated behaviors, but how cortico-collicular pathways coordinate SC activity at the cellular level is poorly understood. Moreover, despite the known role of the SC as a multisensory integrator, the involvement of the SC in the somatosensory system is largely unexplored in comparison to its involvement in the visual and auditory systems. Here, we mapped the input-output properties of the whisker-sensitive region of the SC in mice with transsynaptic and intersectional tracing tools and in vivo electrophysiology. The results reveal a novel trans-collicular connectivity motif by which neurons in motor- and somatosensory cortices impinge onto the brainstem-SC-brainstem sensory-motor arc and onto SC-midbrain output pathways via only one synapse in the SC. Intersectional approaches and optogenetically assisted connectivity quantifications in vivo reveal convergence of motor and somatosensory cortical input on individual SC neurons, providing a new framework for sensory-motor integration in the SC. More than a third of the cortical recipient neurons in the whisker SC are GABAergic neurons, which accommodate hitherto unknown GABAergic projection neurons, targeting thalamic nuclei and the zona incerta. These results pinpoint a whisker region in the SC of mice as a node for the integration of somatosensory and motor cortical signals via parallel excitatory and inhibitory trans-collicular pathways which link cortical and subcortical whisker circuits for somato-motor integration.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
This dataset contains electrophysiological spike time data and figure data for anatomical quantifications reported in Martín-Cortecero et al. Monosynaptic trans-collicular pathways for sensory-motor integration in the whisker system(2023).Abstract: The superior colliculus (SC), a conserved midbrain-node with extensive long-range connectivity throughout the brain, is a key structure for innate behaviors. Descending cortical pathways are increasingly recognized as central control points for SC-mediated behaviors, but how cortico-collicular pathways coordinate SC activity at the cellular level is poorly understood. Moreover, despite the known role of the SC as a multisensory integrator, the involvement of the SC in the somatosensory system is largely unexplored in comparison to its involvement in the visual and auditory systems. Here, we mapped the input-output properties of the whisker-sensitive region of the SC in mice with transsynaptic and intersectional tracing tools and in vivo electrophysiology. The results reveal a novel trans-collicular connectivity motif by which neurons in motor- and somatosensory cortices impinge onto the brainstem-SC-brainstem sensory-motor arc and onto SC-midbrain output pathways via only one synapse in the SC. Intersectional approaches and optogenetically assisted connectivity quantifications in vivo reveal convergence of motor and somatosensory cortical input on individual SC neurons, providing a new framework for sensory-motor integration in the SC. More than a third of the cortical recipient neurons in the whisker SC are GABAergic neurons, which accommodate hitherto unknown GABAergic projection neurons, targeting thalamic nuclei and the zona incerta. These results pinpoint a whisker region in the SC of mice as a node for the integration of somatosensory and motor cortical signals via parallel excitatory and inhibitory trans-collicular pathways which link cortical and subcortical whisker circuits for somato-motor integration.
|
Medicine, Health and Life Sciences
|
optogenetics; sensory circuits; sensory-motor convergence; spike time data; superior colliculus; whisker system
|
doi:10.11588/data/EIXOPN
|
Key Signature Genes of Early Terminal Granulocytic Differentiation Distinguish Sepsis from SIRS on ICU Admission
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Background: Infection can induce granulopoiesis. This process potentially gives rise to blood gene classifiers of sepsis in systemic inflammatory response syndrome (SIRS) patients. The aim of this study was to identify sepsis signature genes in blood granulocytes from patients with sepsis and SIRS on intensive care unit (ICU) admission.Methods: CD15+ cells encompassing all stage of terminal granulocytic differentiation were analyzed. CD15 transcriptomes from patients with sepsis and SIRS on ICU admission and presurgical controls (discovery cohort) were subjected to differential gene expression and pathway enrichment analyses. Differential expression was validated by bead array in independent sepsis and SIRS patients (validation cohort). We referred to the GeneCards database for subcellular gene associations and Grassi et al. (Cell Rep 2018; 24: 2784-2794) for granule signature genes. Blood counts of granulocyte precursors were determined by flow cytometry in a validation cohort subset.Results: Despite similar transcriptional CD15 responses in sepsis and SIRS, enrichment of pathways known to decline at the metamyelocyte stage (mitochondrial, lysosome, cell cycle, proteasome) was associated with sepsis but not SIRS. Twelve of 30 validated genes, from 100 selected for changes in response to sepsis rather than SIRS, were endo-lysosomal. Revisiting the discovery transcriptomes revealed elevated expression of promyelocyte-restricted azurophilic granule genes in sepsis and myelocyte-restricted specific granule genes in sepsis followed by SIRS. Blood counts of promyelocytes and myelocytes were higher in sepsis than SIRS. Conclusions: Sepsis-induced granulopoiesis and signature genes of early terminal granulocytic differentiation provide a rationale for classifiers of sepsis in patients with SIRS on ICU admission. Yet, distinction of this process from non-infectious tissue injury-induced granulopoiesis remains to be investigated.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'granulocytes; intensive care unit; sepsis; signature genes; systemic inflammatory response syndrome'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Key Signature Genes of Early Terminal Granulocytic Differentiation Distinguish Sepsis from SIRS on ICU Admission' Description:'Background: Infection can induce granulopoiesis. This process potentially gives rise to blood gene classifiers of sepsis in systemic inflammatory response syndrome (SIRS) patients. The aim of this study was to identify sepsis signature genes in blood granulocytes from patients with sepsis and SIRS on intensive care unit (ICU) admission.Methods: CD15+ cells encompassing all stage of terminal granulocytic differentiation were analyzed. CD15 transcriptomes from patients with sepsis and SIRS on ICU admission and presurgical controls (discovery cohort) were subjected to differential gene expression and pathway enrichment analyses. Differential expression was validated by bead array in independent sepsis and SIRS patients (validation cohort). We referred to the GeneCards database for subcellular gene associations and Grassi et al. (Cell Rep 2018; 24: 2784-2794) for granule signature genes. Blood counts of granulocyte precursors were determined by flow cytometry in a validation cohort subset.Results: Despite similar transcriptional CD15 responses in sepsis and SIRS, enrichment of pathways known to decline at the metamyelocyte stage (mitochondrial, lysosome, cell cycle, proteasome) was associated with sepsis but not SIRS. Twelve of 30 validated genes, from 100 selected for changes in response to sepsis rather than SIRS, were endo-lysosomal. Revisiting the discovery transcriptomes revealed elevated expression of promyelocyte-restricted azurophilic granule genes in sepsis and myelocyte-restricted specific granule genes in sepsis followed by SIRS. Blood counts of promyelocytes and myelocytes were higher in sepsis than SIRS. Conclusions: Sepsis-induced granulopoiesis and signature genes of early terminal granulocytic differentiation provide a rationale for classifiers of sepsis in patients with SIRS on ICU admission. Yet, distinction of this process from non-infectious tissue injury-induced granulopoiesis remains to be investigated.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Background: Infection can induce granulopoiesis. This process potentially gives rise to blood gene classifiers of sepsis in systemic inflammatory response syndrome (SIRS) patients. The aim of this study was to identify sepsis signature genes in blood granulocytes from patients with sepsis and SIRS on intensive care unit (ICU) admission.Methods: CD15+ cells encompassing all stage of terminal granulocytic differentiation were analyzed. CD15 transcriptomes from patients with sepsis and SIRS on ICU admission and presurgical controls (discovery cohort) were subjected to differential gene expression and pathway enrichment analyses. Differential expression was validated by bead array in independent sepsis and SIRS patients (validation cohort). We referred to the GeneCards database for subcellular gene associations and Grassi et al. (Cell Rep 2018; 24: 2784-2794) for granule signature genes. Blood counts of granulocyte precursors were determined by flow cytometry in a validation cohort subset.Results: Despite similar transcriptional CD15 responses in sepsis and SIRS, enrichment of pathways known to decline at the metamyelocyte stage (mitochondrial, lysosome, cell cycle, proteasome) was associated with sepsis but not SIRS. Twelve of 30 validated genes, from 100 selected for changes in response to sepsis rather than SIRS, were endo-lysosomal. Revisiting the discovery transcriptomes revealed elevated expression of promyelocyte-restricted azurophilic granule genes in sepsis and myelocyte-restricted specific granule genes in sepsis followed by SIRS. Blood counts of promyelocytes and myelocytes were higher in sepsis than SIRS. Conclusions: Sepsis-induced granulopoiesis and signature genes of early terminal granulocytic differentiation provide a rationale for classifiers of sepsis in patients with SIRS on ICU admission. Yet, distinction of this process from non-infectious tissue injury-induced granulopoiesis remains to be investigated.
|
Medicine, Health and Life Sciences
|
granulocytes; intensive care unit; sepsis; signature genes; systemic inflammatory response syndrome
|
doi:10.11588/data/FHOCRZ
|
Raw data and analysis scripts for 'Design and application of an MR reference phantom for multicentre lung imaging trials'
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'This dataset contains all MRI phantom data discussed in the related publication as well as the python scripts used to analyse them. The format is DICOM files, where institution names and adresses have been anonymized.AbstractIntroduction:As there is an increasing number of multicentre lung imaging studies with MRI in patients, dedicated reference phantoms are required to allow for the assessment and comparison of image quality in multi-vendor and multi-centre environments. However, appropriate phantoms for this purpose are so far not available commercially. It was therefore the purpose of this project to design and evaluate a cost-effective and simple to use reference phantom which addresses the specific requirements for imaging the lungs with MRI.Methods:We designed and employed a cost-effective and simple to use reference phantom specifically for the demands of chest MRI, simulating 4 compartments (lung, blood, muscle and fat) which reflect the specific conditions in proton-MRI of the chest. Multiple phantom instances were produced and measured at 15 sites using a complete proton-MRI protocol designed for an in vivo COPD study at intervals over the course of the study. Measures of signal- and contrast-to-noise ratio, as well as structure and edge depiction were extracted from conventionally acquired images using software written for this purpose.Results:For the signal to noise ratio, low (short-term) intra-scanner variability was found with, 4.5% in the lung compartment, 4.0% for blood, 3.3% for muscle and 3.7% for fat. The inter-scanner variability was substantially higher, with 41%, 32% 27% and 32% for the same order of compartments. In addition, measures of structure and edge depiction were found to both vary significantly among several scanner types and among scanners of the same model which were equipped with different gradient systems.Conclusion:The described reference phantom detected substantial inter-scanner variability in a current multicentre proton MRI study of the lung. Accordingly, the use of an appropriate reference phantom is advised and the extent of variability in image quality should be considered when interpreting results of such imaging studies.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'lung imaging; MR phantoms; multicentre trials'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Raw data and analysis scripts for 'Design and application of an MR reference phantom for multicentre lung imaging trials'' Description:'This dataset contains all MRI phantom data discussed in the related publication as well as the python scripts used to analyse them. The format is DICOM files, where institution names and adresses have been anonymized.AbstractIntroduction:As there is an increasing number of multicentre lung imaging studies with MRI in patients, dedicated reference phantoms are required to allow for the assessment and comparison of image quality in multi-vendor and multi-centre environments. However, appropriate phantoms for this purpose are so far not available commercially. It was therefore the purpose of this project to design and evaluate a cost-effective and simple to use reference phantom which addresses the specific requirements for imaging the lungs with MRI.Methods:We designed and employed a cost-effective and simple to use reference phantom specifically for the demands of chest MRI, simulating 4 compartments (lung, blood, muscle and fat) which reflect the specific conditions in proton-MRI of the chest. Multiple phantom instances were produced and measured at 15 sites using a complete proton-MRI protocol designed for an in vivo COPD study at intervals over the course of the study. Measures of signal- and contrast-to-noise ratio, as well as structure and edge depiction were extracted from conventionally acquired images using software written for this purpose.Results:For the signal to noise ratio, low (short-term) intra-scanner variability was found with, 4.5% in the lung compartment, 4.0% for blood, 3.3% for muscle and 3.7% for fat. The inter-scanner variability was substantially higher, with 41%, 32% 27% and 32% for the same order of compartments. In addition, measures of structure and edge depiction were found to both vary significantly among several scanner types and among scanners of the same model which were equipped with different gradient systems.Conclusion:The described reference phantom detected substantial inter-scanner variability in a current multicentre proton MRI study of the lung. Accordingly, the use of an appropriate reference phantom is advised and the extent of variability in image quality should be considered when interpreting results of such imaging studies.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
This dataset contains all MRI phantom data discussed in the related publication as well as the python scripts used to analyse them. The format is DICOM files, where institution names and adresses have been anonymized.AbstractIntroduction:As there is an increasing number of multicentre lung imaging studies with MRI in patients, dedicated reference phantoms are required to allow for the assessment and comparison of image quality in multi-vendor and multi-centre environments. However, appropriate phantoms for this purpose are so far not available commercially. It was therefore the purpose of this project to design and evaluate a cost-effective and simple to use reference phantom which addresses the specific requirements for imaging the lungs with MRI.Methods:We designed and employed a cost-effective and simple to use reference phantom specifically for the demands of chest MRI, simulating 4 compartments (lung, blood, muscle and fat) which reflect the specific conditions in proton-MRI of the chest. Multiple phantom instances were produced and measured at 15 sites using a complete proton-MRI protocol designed for an in vivo COPD study at intervals over the course of the study. Measures of signal- and contrast-to-noise ratio, as well as structure and edge depiction were extracted from conventionally acquired images using software written for this purpose.Results:For the signal to noise ratio, low (short-term) intra-scanner variability was found with, 4.5% in the lung compartment, 4.0% for blood, 3.3% for muscle and 3.7% for fat. The inter-scanner variability was substantially higher, with 41%, 32% 27% and 32% for the same order of compartments. In addition, measures of structure and edge depiction were found to both vary significantly among several scanner types and among scanners of the same model which were equipped with different gradient systems.Conclusion:The described reference phantom detected substantial inter-scanner variability in a current multicentre proton MRI study of the lung. Accordingly, the use of an appropriate reference phantom is advised and the extent of variability in image quality should be considered when interpreting results of such imaging studies.
|
Medicine, Health and Life Sciences
|
lung imaging; MR phantoms; multicentre trials
|
doi:10.11588/data/FHOCRZ
|
Raw data and analysis scripts for 'Design and application of an MR reference phantom for multicentre lung imaging trials'
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'This dataset contains all MRI phantom data discussed in the related publication as well as the python scripts used to analyse them. The format is DICOM files, where institution names and adresses have been anonymized.AbstractIntroduction:As there is an increasing number of multicentre lung imaging studies with MRI in patients, dedicated reference phantoms are required to allow for the assessment and comparison of image quality in multi-vendor and multi-centre environments. However, appropriate phantoms for this purpose are so far not available commercially. It was therefore the purpose of this project to design and evaluate a cost-effective and simple to use reference phantom which addresses the specific requirements for imaging the lungs with MRI.Methods:We designed and employed a cost-effective and simple to use reference phantom specifically for the demands of chest MRI, simulating 4 compartments (lung, blood, muscle and fat) which reflect the specific conditions in proton-MRI of the chest. Multiple phantom instances were produced and measured at 15 sites using a complete proton-MRI protocol designed for an in vivo COPD study at intervals over the course of the study. Measures of signal- and contrast-to-noise ratio, as well as structure and edge depiction were extracted from conventionally acquired images using software written for this purpose.Results:For the signal to noise ratio, low (short-term) intra-scanner variability was found with, 4.5% in the lung compartment, 4.0% for blood, 3.3% for muscle and 3.7% for fat. The inter-scanner variability was substantially higher, with 41%, 32% 27% and 32% for the same order of compartments. In addition, measures of structure and edge depiction were found to both vary significantly among several scanner types and among scanners of the same model which were equipped with different gradient systems.Conclusion:The described reference phantom detected substantial inter-scanner variability in a current multicentre proton MRI study of the lung. Accordingly, the use of an appropriate reference phantom is advised and the extent of variability in image quality should be considered when interpreting results of such imaging studies.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'lung imaging; MR phantoms; multicentre trials'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Raw data and analysis scripts for 'Design and application of an MR reference phantom for multicentre lung imaging trials'' Description:'This dataset contains all MRI phantom data discussed in the related publication as well as the python scripts used to analyse them. The format is DICOM files, where institution names and adresses have been anonymized.AbstractIntroduction:As there is an increasing number of multicentre lung imaging studies with MRI in patients, dedicated reference phantoms are required to allow for the assessment and comparison of image quality in multi-vendor and multi-centre environments. However, appropriate phantoms for this purpose are so far not available commercially. It was therefore the purpose of this project to design and evaluate a cost-effective and simple to use reference phantom which addresses the specific requirements for imaging the lungs with MRI.Methods:We designed and employed a cost-effective and simple to use reference phantom specifically for the demands of chest MRI, simulating 4 compartments (lung, blood, muscle and fat) which reflect the specific conditions in proton-MRI of the chest. Multiple phantom instances were produced and measured at 15 sites using a complete proton-MRI protocol designed for an in vivo COPD study at intervals over the course of the study. Measures of signal- and contrast-to-noise ratio, as well as structure and edge depiction were extracted from conventionally acquired images using software written for this purpose.Results:For the signal to noise ratio, low (short-term) intra-scanner variability was found with, 4.5% in the lung compartment, 4.0% for blood, 3.3% for muscle and 3.7% for fat. The inter-scanner variability was substantially higher, with 41%, 32% 27% and 32% for the same order of compartments. In addition, measures of structure and edge depiction were found to both vary significantly among several scanner types and among scanners of the same model which were equipped with different gradient systems.Conclusion:The described reference phantom detected substantial inter-scanner variability in a current multicentre proton MRI study of the lung. Accordingly, the use of an appropriate reference phantom is advised and the extent of variability in image quality should be considered when interpreting results of such imaging studies.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
This dataset contains all MRI phantom data discussed in the related publication as well as the python scripts used to analyse them. The format is DICOM files, where institution names and adresses have been anonymized.AbstractIntroduction:As there is an increasing number of multicentre lung imaging studies with MRI in patients, dedicated reference phantoms are required to allow for the assessment and comparison of image quality in multi-vendor and multi-centre environments. However, appropriate phantoms for this purpose are so far not available commercially. It was therefore the purpose of this project to design and evaluate a cost-effective and simple to use reference phantom which addresses the specific requirements for imaging the lungs with MRI.Methods:We designed and employed a cost-effective and simple to use reference phantom specifically for the demands of chest MRI, simulating 4 compartments (lung, blood, muscle and fat) which reflect the specific conditions in proton-MRI of the chest. Multiple phantom instances were produced and measured at 15 sites using a complete proton-MRI protocol designed for an in vivo COPD study at intervals over the course of the study. Measures of signal- and contrast-to-noise ratio, as well as structure and edge depiction were extracted from conventionally acquired images using software written for this purpose.Results:For the signal to noise ratio, low (short-term) intra-scanner variability was found with, 4.5% in the lung compartment, 4.0% for blood, 3.3% for muscle and 3.7% for fat. The inter-scanner variability was substantially higher, with 41%, 32% 27% and 32% for the same order of compartments. In addition, measures of structure and edge depiction were found to both vary significantly among several scanner types and among scanners of the same model which were equipped with different gradient systems.Conclusion:The described reference phantom detected substantial inter-scanner variability in a current multicentre proton MRI study of the lung. Accordingly, the use of an appropriate reference phantom is advised and the extent of variability in image quality should be considered when interpreting results of such imaging studies.
|
Medicine, Health and Life Sciences
|
lung imaging; MR phantoms; multicentre trials
|
doi:10.11588/data/FSPQL4
|
The Abbott PanBio WHO emergency use listed, rapid, antigen-detecting point-of-care diagnostic test for SARS-CoV-2 - Evaluation of the accuracy and ease-of-use [Research Data]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'This repository includes data from a prospective, multi-centre diagnostic accuracy study. The study was conducted at two sites in Germany, Heidelberg and Berlin. Following routine testing with reverse-transcriptase polymerase chain reaction (RT-PCR), a second study-exclusive swab was performed for Ag-RDT testing. Routine swabs were nasopharyngeal (NP) or combined NP/oropharyngeal (OP) whereas the study-exclusive swabs were NP. To evaluate performance, sensitivity and specificity were assessed overall and in predefined sub analyses accordingly to cycle-threshold values, days of symptoms, disease severity and study site. In addition, further data from the participants were collected during interviews.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Antigen-detecting; Covid-19; Diagnostics; SARS-CoV-2'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'The Abbott PanBio WHO emergency use listed, rapid, antigen-detecting point-of-care diagnostic test for SARS-CoV-2 - Evaluation of the accuracy and ease-of-use [Research Data]' Description:'This repository includes data from a prospective, multi-centre diagnostic accuracy study. The study was conducted at two sites in Germany, Heidelberg and Berlin. Following routine testing with reverse-transcriptase polymerase chain reaction (RT-PCR), a second study-exclusive swab was performed for Ag-RDT testing. Routine swabs were nasopharyngeal (NP) or combined NP/oropharyngeal (OP) whereas the study-exclusive swabs were NP. To evaluate performance, sensitivity and specificity were assessed overall and in predefined sub analyses accordingly to cycle-threshold values, days of symptoms, disease severity and study site. In addition, further data from the participants were collected during interviews.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
This repository includes data from a prospective, multi-centre diagnostic accuracy study. The study was conducted at two sites in Germany, Heidelberg and Berlin. Following routine testing with reverse-transcriptase polymerase chain reaction (RT-PCR), a second study-exclusive swab was performed for Ag-RDT testing. Routine swabs were nasopharyngeal (NP) or combined NP/oropharyngeal (OP) whereas the study-exclusive swabs were NP. To evaluate performance, sensitivity and specificity were assessed overall and in predefined sub analyses accordingly to cycle-threshold values, days of symptoms, disease severity and study site. In addition, further data from the participants were collected during interviews.
|
Medicine, Health and Life Sciences
|
Antigen-detecting; Covid-19; Diagnostics; SARS-CoV-2
|
doi:10.11588/data/GEEBLZ
|
Social and Cognitive Congruence [Data]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'This dataset contains the R-Script of our Evaluation and the dataset on which our results are based.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Peer-Assisted Learning; Social and Cognitive Congruence'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Social and Cognitive Congruence [Data]' Description:'This dataset contains the R-Script of our Evaluation and the dataset on which our results are based.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
This dataset contains the R-Script of our Evaluation and the dataset on which our results are based.
|
Medicine, Health and Life Sciences
|
Peer-Assisted Learning; Social and Cognitive Congruence
|
doi:10.11588/data/HJ6SVM
|
Collagen breaks at weak sacrificial bonds taming its mechanoradicals [Data]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'This dataset contains input files for MD simulations, derived breakage counts from these simulations that are used to generate the figures in the publication, and the experimental, uncropped SDS-PAGE gels of the presented results in the related publication. Abstract of related publication: Collagen is a force-bearing, hierarchical structural protein important to all connective tissue. In tendon collagen, high load even below macroscopic failure level creates mechanoradicals by homolytic bond scission, similar to polymers. The location and type of initial rupture sites critically decide on both the mechanical and chemical impact of these micro-ruptures on the tissue, but are yet to be explored. Wehere use scale-bridging simulations supported by gel electrophoresis and mass spectrometry to determine breakage points in collagen. We find collagen crosslinks, as opposed to the backbone, to harbor the weakest bonds, with one particular bond in trivalent crosslinks as the most dominant rupture site. We identify this bond as sacrificial, rupturing prior to other bonds while maintaining the material’s integrity.Also, collagen’s weak bonds funnel ruptures such that the potentially harmful mechanoradicals are readily stabilized. Our results suggest this unique failure mode of collagen to be tailored towards combatting an early onset of macroscopic failure and material ageing.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Collagen; KIMMDY; Mechanoracials; Molecular Dynamics'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Collagen breaks at weak sacrificial bonds taming its mechanoradicals [Data]' Description:'This dataset contains input files for MD simulations, derived breakage counts from these simulations that are used to generate the figures in the publication, and the experimental, uncropped SDS-PAGE gels of the presented results in the related publication. Abstract of related publication: Collagen is a force-bearing, hierarchical structural protein important to all connective tissue. In tendon collagen, high load even below macroscopic failure level creates mechanoradicals by homolytic bond scission, similar to polymers. The location and type of initial rupture sites critically decide on both the mechanical and chemical impact of these micro-ruptures on the tissue, but are yet to be explored. Wehere use scale-bridging simulations supported by gel electrophoresis and mass spectrometry to determine breakage points in collagen. We find collagen crosslinks, as opposed to the backbone, to harbor the weakest bonds, with one particular bond in trivalent crosslinks as the most dominant rupture site. We identify this bond as sacrificial, rupturing prior to other bonds while maintaining the material’s integrity.Also, collagen’s weak bonds funnel ruptures such that the potentially harmful mechanoradicals are readily stabilized. Our results suggest this unique failure mode of collagen to be tailored towards combatting an early onset of macroscopic failure and material ageing.' Subject:'Chemistry; Computer and Information Science; Medicine, Health and Life Sciences; Physics. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
This dataset contains input files for MD simulations, derived breakage counts from these simulations that are used to generate the figures in the publication, and the experimental, uncropped SDS-PAGE gels of the presented results in the related publication. Abstract of related publication: Collagen is a force-bearing, hierarchical structural protein important to all connective tissue. In tendon collagen, high load even below macroscopic failure level creates mechanoradicals by homolytic bond scission, similar to polymers. The location and type of initial rupture sites critically decide on both the mechanical and chemical impact of these micro-ruptures on the tissue, but are yet to be explored. Wehere use scale-bridging simulations supported by gel electrophoresis and mass spectrometry to determine breakage points in collagen. We find collagen crosslinks, as opposed to the backbone, to harbor the weakest bonds, with one particular bond in trivalent crosslinks as the most dominant rupture site. We identify this bond as sacrificial, rupturing prior to other bonds while maintaining the material’s integrity.Also, collagen’s weak bonds funnel ruptures such that the potentially harmful mechanoradicals are readily stabilized. Our results suggest this unique failure mode of collagen to be tailored towards combatting an early onset of macroscopic failure and material ageing.
|
Chemistry
|
Collagen; KIMMDY; Mechanoracials; Molecular Dynamics
|
doi:10.11588/data/HJ6SVM
|
Collagen breaks at weak sacrificial bonds taming its mechanoradicals [Data]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'This dataset contains input files for MD simulations, derived breakage counts from these simulations that are used to generate the figures in the publication, and the experimental, uncropped SDS-PAGE gels of the presented results in the related publication. Abstract of related publication: Collagen is a force-bearing, hierarchical structural protein important to all connective tissue. In tendon collagen, high load even below macroscopic failure level creates mechanoradicals by homolytic bond scission, similar to polymers. The location and type of initial rupture sites critically decide on both the mechanical and chemical impact of these micro-ruptures on the tissue, but are yet to be explored. Wehere use scale-bridging simulations supported by gel electrophoresis and mass spectrometry to determine breakage points in collagen. We find collagen crosslinks, as opposed to the backbone, to harbor the weakest bonds, with one particular bond in trivalent crosslinks as the most dominant rupture site. We identify this bond as sacrificial, rupturing prior to other bonds while maintaining the material’s integrity.Also, collagen’s weak bonds funnel ruptures such that the potentially harmful mechanoradicals are readily stabilized. Our results suggest this unique failure mode of collagen to be tailored towards combatting an early onset of macroscopic failure and material ageing.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Collagen; KIMMDY; Mechanoracials; Molecular Dynamics'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Collagen breaks at weak sacrificial bonds taming its mechanoradicals [Data]' Description:'This dataset contains input files for MD simulations, derived breakage counts from these simulations that are used to generate the figures in the publication, and the experimental, uncropped SDS-PAGE gels of the presented results in the related publication. Abstract of related publication: Collagen is a force-bearing, hierarchical structural protein important to all connective tissue. In tendon collagen, high load even below macroscopic failure level creates mechanoradicals by homolytic bond scission, similar to polymers. The location and type of initial rupture sites critically decide on both the mechanical and chemical impact of these micro-ruptures on the tissue, but are yet to be explored. Wehere use scale-bridging simulations supported by gel electrophoresis and mass spectrometry to determine breakage points in collagen. We find collagen crosslinks, as opposed to the backbone, to harbor the weakest bonds, with one particular bond in trivalent crosslinks as the most dominant rupture site. We identify this bond as sacrificial, rupturing prior to other bonds while maintaining the material’s integrity.Also, collagen’s weak bonds funnel ruptures such that the potentially harmful mechanoradicals are readily stabilized. Our results suggest this unique failure mode of collagen to be tailored towards combatting an early onset of macroscopic failure and material ageing.' Subject:'Chemistry; Computer and Information Science; Medicine, Health and Life Sciences; Physics. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
This dataset contains input files for MD simulations, derived breakage counts from these simulations that are used to generate the figures in the publication, and the experimental, uncropped SDS-PAGE gels of the presented results in the related publication. Abstract of related publication: Collagen is a force-bearing, hierarchical structural protein important to all connective tissue. In tendon collagen, high load even below macroscopic failure level creates mechanoradicals by homolytic bond scission, similar to polymers. The location and type of initial rupture sites critically decide on both the mechanical and chemical impact of these micro-ruptures on the tissue, but are yet to be explored. Wehere use scale-bridging simulations supported by gel electrophoresis and mass spectrometry to determine breakage points in collagen. We find collagen crosslinks, as opposed to the backbone, to harbor the weakest bonds, with one particular bond in trivalent crosslinks as the most dominant rupture site. We identify this bond as sacrificial, rupturing prior to other bonds while maintaining the material’s integrity.Also, collagen’s weak bonds funnel ruptures such that the potentially harmful mechanoradicals are readily stabilized. Our results suggest this unique failure mode of collagen to be tailored towards combatting an early onset of macroscopic failure and material ageing.
|
Computer and Information Science
|
Collagen; KIMMDY; Mechanoracials; Molecular Dynamics
|
doi:10.11588/data/HJ6SVM
|
Collagen breaks at weak sacrificial bonds taming its mechanoradicals [Data]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'This dataset contains input files for MD simulations, derived breakage counts from these simulations that are used to generate the figures in the publication, and the experimental, uncropped SDS-PAGE gels of the presented results in the related publication. Abstract of related publication: Collagen is a force-bearing, hierarchical structural protein important to all connective tissue. In tendon collagen, high load even below macroscopic failure level creates mechanoradicals by homolytic bond scission, similar to polymers. The location and type of initial rupture sites critically decide on both the mechanical and chemical impact of these micro-ruptures on the tissue, but are yet to be explored. Wehere use scale-bridging simulations supported by gel electrophoresis and mass spectrometry to determine breakage points in collagen. We find collagen crosslinks, as opposed to the backbone, to harbor the weakest bonds, with one particular bond in trivalent crosslinks as the most dominant rupture site. We identify this bond as sacrificial, rupturing prior to other bonds while maintaining the material’s integrity.Also, collagen’s weak bonds funnel ruptures such that the potentially harmful mechanoradicals are readily stabilized. Our results suggest this unique failure mode of collagen to be tailored towards combatting an early onset of macroscopic failure and material ageing.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Collagen; KIMMDY; Mechanoracials; Molecular Dynamics'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Collagen breaks at weak sacrificial bonds taming its mechanoradicals [Data]' Description:'This dataset contains input files for MD simulations, derived breakage counts from these simulations that are used to generate the figures in the publication, and the experimental, uncropped SDS-PAGE gels of the presented results in the related publication. Abstract of related publication: Collagen is a force-bearing, hierarchical structural protein important to all connective tissue. In tendon collagen, high load even below macroscopic failure level creates mechanoradicals by homolytic bond scission, similar to polymers. The location and type of initial rupture sites critically decide on both the mechanical and chemical impact of these micro-ruptures on the tissue, but are yet to be explored. Wehere use scale-bridging simulations supported by gel electrophoresis and mass spectrometry to determine breakage points in collagen. We find collagen crosslinks, as opposed to the backbone, to harbor the weakest bonds, with one particular bond in trivalent crosslinks as the most dominant rupture site. We identify this bond as sacrificial, rupturing prior to other bonds while maintaining the material’s integrity.Also, collagen’s weak bonds funnel ruptures such that the potentially harmful mechanoradicals are readily stabilized. Our results suggest this unique failure mode of collagen to be tailored towards combatting an early onset of macroscopic failure and material ageing.' Subject:'Chemistry; Computer and Information Science; Medicine, Health and Life Sciences; Physics. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
This dataset contains input files for MD simulations, derived breakage counts from these simulations that are used to generate the figures in the publication, and the experimental, uncropped SDS-PAGE gels of the presented results in the related publication. Abstract of related publication: Collagen is a force-bearing, hierarchical structural protein important to all connective tissue. In tendon collagen, high load even below macroscopic failure level creates mechanoradicals by homolytic bond scission, similar to polymers. The location and type of initial rupture sites critically decide on both the mechanical and chemical impact of these micro-ruptures on the tissue, but are yet to be explored. Wehere use scale-bridging simulations supported by gel electrophoresis and mass spectrometry to determine breakage points in collagen. We find collagen crosslinks, as opposed to the backbone, to harbor the weakest bonds, with one particular bond in trivalent crosslinks as the most dominant rupture site. We identify this bond as sacrificial, rupturing prior to other bonds while maintaining the material’s integrity.Also, collagen’s weak bonds funnel ruptures such that the potentially harmful mechanoradicals are readily stabilized. Our results suggest this unique failure mode of collagen to be tailored towards combatting an early onset of macroscopic failure and material ageing.
|
Medicine, Health and Life Sciences
|
Collagen; KIMMDY; Mechanoracials; Molecular Dynamics
|
doi:10.11588/data/HJ6SVM
|
Collagen breaks at weak sacrificial bonds taming its mechanoradicals [Data]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'This dataset contains input files for MD simulations, derived breakage counts from these simulations that are used to generate the figures in the publication, and the experimental, uncropped SDS-PAGE gels of the presented results in the related publication. Abstract of related publication: Collagen is a force-bearing, hierarchical structural protein important to all connective tissue. In tendon collagen, high load even below macroscopic failure level creates mechanoradicals by homolytic bond scission, similar to polymers. The location and type of initial rupture sites critically decide on both the mechanical and chemical impact of these micro-ruptures on the tissue, but are yet to be explored. Wehere use scale-bridging simulations supported by gel electrophoresis and mass spectrometry to determine breakage points in collagen. We find collagen crosslinks, as opposed to the backbone, to harbor the weakest bonds, with one particular bond in trivalent crosslinks as the most dominant rupture site. We identify this bond as sacrificial, rupturing prior to other bonds while maintaining the material’s integrity.Also, collagen’s weak bonds funnel ruptures such that the potentially harmful mechanoradicals are readily stabilized. Our results suggest this unique failure mode of collagen to be tailored towards combatting an early onset of macroscopic failure and material ageing.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Collagen; KIMMDY; Mechanoracials; Molecular Dynamics'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Collagen breaks at weak sacrificial bonds taming its mechanoradicals [Data]' Description:'This dataset contains input files for MD simulations, derived breakage counts from these simulations that are used to generate the figures in the publication, and the experimental, uncropped SDS-PAGE gels of the presented results in the related publication. Abstract of related publication: Collagen is a force-bearing, hierarchical structural protein important to all connective tissue. In tendon collagen, high load even below macroscopic failure level creates mechanoradicals by homolytic bond scission, similar to polymers. The location and type of initial rupture sites critically decide on both the mechanical and chemical impact of these micro-ruptures on the tissue, but are yet to be explored. Wehere use scale-bridging simulations supported by gel electrophoresis and mass spectrometry to determine breakage points in collagen. We find collagen crosslinks, as opposed to the backbone, to harbor the weakest bonds, with one particular bond in trivalent crosslinks as the most dominant rupture site. We identify this bond as sacrificial, rupturing prior to other bonds while maintaining the material’s integrity.Also, collagen’s weak bonds funnel ruptures such that the potentially harmful mechanoradicals are readily stabilized. Our results suggest this unique failure mode of collagen to be tailored towards combatting an early onset of macroscopic failure and material ageing.' Subject:'Chemistry; Computer and Information Science; Medicine, Health and Life Sciences; Physics. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
This dataset contains input files for MD simulations, derived breakage counts from these simulations that are used to generate the figures in the publication, and the experimental, uncropped SDS-PAGE gels of the presented results in the related publication. Abstract of related publication: Collagen is a force-bearing, hierarchical structural protein important to all connective tissue. In tendon collagen, high load even below macroscopic failure level creates mechanoradicals by homolytic bond scission, similar to polymers. The location and type of initial rupture sites critically decide on both the mechanical and chemical impact of these micro-ruptures on the tissue, but are yet to be explored. Wehere use scale-bridging simulations supported by gel electrophoresis and mass spectrometry to determine breakage points in collagen. We find collagen crosslinks, as opposed to the backbone, to harbor the weakest bonds, with one particular bond in trivalent crosslinks as the most dominant rupture site. We identify this bond as sacrificial, rupturing prior to other bonds while maintaining the material’s integrity.Also, collagen’s weak bonds funnel ruptures such that the potentially harmful mechanoradicals are readily stabilized. Our results suggest this unique failure mode of collagen to be tailored towards combatting an early onset of macroscopic failure and material ageing.
|
Physics
|
Collagen; KIMMDY; Mechanoracials; Molecular Dynamics
|
doi:10.11588/data/ICSFUS
|
Multimodal ground truth datasets for abdominal medical image registration [data]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Sparsity of annotated data is a major limitation in medical image processing tasks such as registration. Registered multimodal image data are essential for the diagnosis of medical conditions and the success of interventional medical procedures. To overcome the shortage of data, we present a method that allows the generation of annotated multimodal 4D datasets.We use a CycleGAN network architecture to generate multimodal synthetic data from the 4D extended cardiac–torso (XCAT) phantom and real patient data. Organ masks are provided by the XCAT phantom; therefore, the generated dataset can serve as ground truth for image segmentation and registration. Compared to real patient data, the synthetic data showed good agreement regarding the image voxel intensity distribution and the noise characteristics. The generated T1-weighted magnetic resonance imaging, computed tomography (CT), and cone beam CT images are inherently co-registered.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'CycleGAN; image registration; image synthesis; liver; multimodal imaging'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Multimodal ground truth datasets for abdominal medical image registration [data]' Description:'Sparsity of annotated data is a major limitation in medical image processing tasks such as registration. Registered multimodal image data are essential for the diagnosis of medical conditions and the success of interventional medical procedures. To overcome the shortage of data, we present a method that allows the generation of annotated multimodal 4D datasets.We use a CycleGAN network architecture to generate multimodal synthetic data from the 4D extended cardiac–torso (XCAT) phantom and real patient data. Organ masks are provided by the XCAT phantom; therefore, the generated dataset can serve as ground truth for image segmentation and registration. Compared to real patient data, the synthetic data showed good agreement regarding the image voxel intensity distribution and the noise characteristics. The generated T1-weighted magnetic resonance imaging, computed tomography (CT), and cone beam CT images are inherently co-registered.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Sparsity of annotated data is a major limitation in medical image processing tasks such as registration. Registered multimodal image data are essential for the diagnosis of medical conditions and the success of interventional medical procedures. To overcome the shortage of data, we present a method that allows the generation of annotated multimodal 4D datasets.We use a CycleGAN network architecture to generate multimodal synthetic data from the 4D extended cardiac–torso (XCAT) phantom and real patient data. Organ masks are provided by the XCAT phantom; therefore, the generated dataset can serve as ground truth for image segmentation and registration. Compared to real patient data, the synthetic data showed good agreement regarding the image voxel intensity distribution and the noise characteristics. The generated T1-weighted magnetic resonance imaging, computed tomography (CT), and cone beam CT images are inherently co-registered.
|
Medicine, Health and Life Sciences
|
CycleGAN; image registration; image synthesis; liver; multimodal imaging
|
doi:10.11588/data/JM2H6I
|
A framework for assessing import costs of medical supplies and results for a tuberculosis program in Karakalpakstan, Uzbekistan [Research Data]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Data and code' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Central Asia; Cost Analysis; Freight Costs; Health program; Humanitarian Aid; Import Costs; Shipping Costs; Supply Chain; Transportation Costs; Tuberculosis; Uzbekistan'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'A framework for assessing import costs of medical supplies and results for a tuberculosis program in Karakalpakstan, Uzbekistan [Research Data]' Description:'Data and code' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Data and code
|
Medicine, Health and Life Sciences
|
Central Asia; Cost Analysis; Freight Costs; Health program; Humanitarian Aid; Import Costs; Shipping Costs; Supply Chain; Transportation Costs; Tuberculosis; Uzbekistan
|
doi:10.11588/data/JWLFFZ
|
Activity of AcD and nonAcD cells during high-frequency network oscillations [data]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Information processing in neuronal networks involves the recruitment of selected neurons into coordinated spatiotemporal activity patterns. This sparse activation results from widespread synaptic inhibition in conjunction with neuron-specific synaptic excitation. We report the selective recruitment of hippocampal pyramidal cells into patterned network activity. During ripple oscillations in awake mice, spiking is much more likely in cells in which the axon originates from a basal dendrite rather than from the soma. High-resolution recordings in vitro and computer modeling indicate that these spikes are elicited by synaptic input to the axon-carrying dendrite and thus escape perisomatic inhibition. Pyramidal cells with somatic axon origin can be activated during ripple oscillations by blocking their somatic inhibition. The recruitment of neurons into active ensembles is thus determined by axonal morphological features.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Axon-carrying Dendrite Cell; Hippocampus; Information Processing; Mice; Perisomatic Inhibition; Pyramidal cells; Ripple Oscillations'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Activity of AcD and nonAcD cells during high-frequency network oscillations [data]' Description:'Information processing in neuronal networks involves the recruitment of selected neurons into coordinated spatiotemporal activity patterns. This sparse activation results from widespread synaptic inhibition in conjunction with neuron-specific synaptic excitation. We report the selective recruitment of hippocampal pyramidal cells into patterned network activity. During ripple oscillations in awake mice, spiking is much more likely in cells in which the axon originates from a basal dendrite rather than from the soma. High-resolution recordings in vitro and computer modeling indicate that these spikes are elicited by synaptic input to the axon-carrying dendrite and thus escape perisomatic inhibition. Pyramidal cells with somatic axon origin can be activated during ripple oscillations by blocking their somatic inhibition. The recruitment of neurons into active ensembles is thus determined by axonal morphological features.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Information processing in neuronal networks involves the recruitment of selected neurons into coordinated spatiotemporal activity patterns. This sparse activation results from widespread synaptic inhibition in conjunction with neuron-specific synaptic excitation. We report the selective recruitment of hippocampal pyramidal cells into patterned network activity. During ripple oscillations in awake mice, spiking is much more likely in cells in which the axon originates from a basal dendrite rather than from the soma. High-resolution recordings in vitro and computer modeling indicate that these spikes are elicited by synaptic input to the axon-carrying dendrite and thus escape perisomatic inhibition. Pyramidal cells with somatic axon origin can be activated during ripple oscillations by blocking their somatic inhibition. The recruitment of neurons into active ensembles is thus determined by axonal morphological features.
|
Medicine, Health and Life Sciences
|
Axon-carrying Dendrite Cell; Hippocampus; Information Processing; Mice; Perisomatic Inhibition; Pyramidal cells; Ripple Oscillations
|
doi:10.11588/data/KRPJ9A
|
Image-based screening for stress granule regulators
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'The supplied macro provides the opportunity to analyse large-scale image datasets, derived from image-based screening approaches. It can be used as a base for the segmentation of individual cells, referred as regions of interest (ROIs), and the detection and quantification of the stress granule (SG) response within those ROIs.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'ImageJ macro, batch analysis, cell segmentation, SG detection and quantification'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Image-based screening for stress granule regulators' Description:'The supplied macro provides the opportunity to analyse large-scale image datasets, derived from image-based screening approaches. It can be used as a base for the segmentation of individual cells, referred as regions of interest (ROIs), and the detection and quantification of the stress granule (SG) response within those ROIs.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
The supplied macro provides the opportunity to analyse large-scale image datasets, derived from image-based screening approaches. It can be used as a base for the segmentation of individual cells, referred as regions of interest (ROIs), and the detection and quantification of the stress granule (SG) response within those ROIs.
|
Medicine, Health and Life Sciences
|
ImageJ macro, batch analysis, cell segmentation, SG detection and quantification
|
doi:10.11588/data/KS5W0H
|
NLP in Diagnostic Texts from Nephropathology [Research Data]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'This data set contains all annotated topic word tables from the work 'NLP in Diagnostic Texts from Nephropathology', as well as all pre-processed and tf-idf-vectorized text files. The raw texts (i.e., descriptive and diagnostic sections) are explicitly not made available, since it cannot be ruled out here that it is possible to infer the patient or the person making the report. This is in accordance with our local ethics committee. Please note: This data set is not yet complete and will be completed soon.Please refer to chapter 3.1.2 of our paper to learn how to interpret the annotated topic word tables.The associated gitlab project http://gitlab.medma.uni-heidelberg.de/mlegnar/nlp-in-diagnostic-texts-from-nephropathology contains some examples of how the .pkl files can be opened and used with python.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'nephropathology; NLP; pathology reports; text analysis; text classification; topic modelling'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'NLP in Diagnostic Texts from Nephropathology [Research Data]' Description:'This data set contains all annotated topic word tables from the work 'NLP in Diagnostic Texts from Nephropathology', as well as all pre-processed and tf-idf-vectorized text files. The raw texts (i.e., descriptive and diagnostic sections) are explicitly not made available, since it cannot be ruled out here that it is possible to infer the patient or the person making the report. This is in accordance with our local ethics committee. Please note: This data set is not yet complete and will be completed soon.Please refer to chapter 3.1.2 of our paper to learn how to interpret the annotated topic word tables.The associated gitlab project http://gitlab.medma.uni-heidelberg.de/mlegnar/nlp-in-diagnostic-texts-from-nephropathology contains some examples of how the .pkl files can be opened and used with python.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
This data set contains all annotated topic word tables from the work 'NLP in Diagnostic Texts from Nephropathology', as well as all pre-processed and tf-idf-vectorized text files. The raw texts (i.e., descriptive and diagnostic sections) are explicitly not made available, since it cannot be ruled out here that it is possible to infer the patient or the person making the report. This is in accordance with our local ethics committee. Please note: This data set is not yet complete and will be completed soon.Please refer to chapter 3.1.2 of our paper to learn how to interpret the annotated topic word tables.The associated gitlab project http://gitlab.medma.uni-heidelberg.de/mlegnar/nlp-in-diagnostic-texts-from-nephropathology contains some examples of how the .pkl files can be opened and used with python.
|
Medicine, Health and Life Sciences
|
nephropathology; NLP; pathology reports; text analysis; text classification; topic modelling
|
doi:10.11588/data/L45TRX
|
Pooled clone collections by multiplexed CRISPR-Cas12a-assisted gene tagging in yeast [Dataset]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Data accompanying the paper 'Pooled clone collections by multiplexed CRISPR-Cas12a-assisted gene tagging in yeast' by Buchmuller and Herbst et al, 2019, Nat Communications. This contains raw NGS data for all genotyping analysis in the publication as well as the source code of the castR design software (v1.0).' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'CRISPR-assisted genome engineering; targeted nex-generation sequencing'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Pooled clone collections by multiplexed CRISPR-Cas12a-assisted gene tagging in yeast [Dataset]' Description:'Data accompanying the paper 'Pooled clone collections by multiplexed CRISPR-Cas12a-assisted gene tagging in yeast' by Buchmuller and Herbst et al, 2019, Nat Communications. This contains raw NGS data for all genotyping analysis in the publication as well as the source code of the castR design software (v1.0).' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Data accompanying the paper 'Pooled clone collections by multiplexed CRISPR-Cas12a-assisted gene tagging in yeast' by Buchmuller and Herbst et al, 2019, Nat Communications. This contains raw NGS data for all genotyping analysis in the publication as well as the source code of the castR design software (v1.0).
|
Medicine, Health and Life Sciences
|
CRISPR-assisted genome engineering; targeted nex-generation sequencing
|
doi:10.11588/data/L5J7WO
|
3D Focusing in Simple Microfluidic Devices for Continuous-flow Single-cell Imaging [data set]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Accompanying data for the manuscript '3D Focusing in Simple Microfluidic Devices for Continuous-flow Single-cell Imaging'.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Imaging Flow Cytometry; Microfluidics'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'3D Focusing in Simple Microfluidic Devices for Continuous-flow Single-cell Imaging [data set]' Description:'Accompanying data for the manuscript '3D Focusing in Simple Microfluidic Devices for Continuous-flow Single-cell Imaging'.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Accompanying data for the manuscript '3D Focusing in Simple Microfluidic Devices for Continuous-flow Single-cell Imaging'.
|
Medicine, Health and Life Sciences
|
Imaging Flow Cytometry; Microfluidics
|
doi:10.11588/data/M2TSIT
|
Neither Carrots nor Sticks? Challenges surrounding Data Sharing from the Perspective of Research Funding Agencies – A Qualitative Expert Interview Study [Interview Excerpts]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'This dataset contains summaries from interviews with data sharing experts from internationa funding agencies on their organisation's data sharing policy.Data Sharing is widely recognised as crucial for accelerating scientific research and improving its quality. However, data sharing is still not a common practice. Funding agencies tend to facilitate the sharing of research data by both providing incentives and requiring data sharing as part of their policies and conditions for awarding grants. The goal of our article is to answer the following question: What challenges do international funding agencies see when it comes to their own efforts to foster and implement data sharing through their policies?We conducted a series of sixteen guideline-based expert interviews with representatives of leading international funding agencies. As contact persons for open science at their respective agencies, they offered their perspectives and experiences concerning their organisations’ data sharing policies. We performed a qualitative content analysis of the interviews and categorised the challenges perceived by funding agencies.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Data Management; Data Sharing; Data Sharing Policies; FAIR Data; Interview study; Qualitative content analysis; Research funders; Research funding agencies'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Neither Carrots nor Sticks? Challenges surrounding Data Sharing from the Perspective of Research Funding Agencies – A Qualitative Expert Interview Study [Interview Excerpts]' Description:'This dataset contains summaries from interviews with data sharing experts from internationa funding agencies on their organisation's data sharing policy.Data Sharing is widely recognised as crucial for accelerating scientific research and improving its quality. However, data sharing is still not a common practice. Funding agencies tend to facilitate the sharing of research data by both providing incentives and requiring data sharing as part of their policies and conditions for awarding grants. The goal of our article is to answer the following question: What challenges do international funding agencies see when it comes to their own efforts to foster and implement data sharing through their policies?We conducted a series of sixteen guideline-based expert interviews with representatives of leading international funding agencies. As contact persons for open science at their respective agencies, they offered their perspectives and experiences concerning their organisations’ data sharing policies. We performed a qualitative content analysis of the interviews and categorised the challenges perceived by funding agencies.' Subject:'Medicine, Health and Life Sciences; Social Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
This dataset contains summaries from interviews with data sharing experts from internationa funding agencies on their organisation's data sharing policy.Data Sharing is widely recognised as crucial for accelerating scientific research and improving its quality. However, data sharing is still not a common practice. Funding agencies tend to facilitate the sharing of research data by both providing incentives and requiring data sharing as part of their policies and conditions for awarding grants. The goal of our article is to answer the following question: What challenges do international funding agencies see when it comes to their own efforts to foster and implement data sharing through their policies?We conducted a series of sixteen guideline-based expert interviews with representatives of leading international funding agencies. As contact persons for open science at their respective agencies, they offered their perspectives and experiences concerning their organisations’ data sharing policies. We performed a qualitative content analysis of the interviews and categorised the challenges perceived by funding agencies.
|
Medicine, Health and Life Sciences
|
Data Management; Data Sharing; Data Sharing Policies; FAIR Data; Interview study; Qualitative content analysis; Research funders; Research funding agencies
|
doi:10.11588/data/M2TSIT
|
Neither Carrots nor Sticks? Challenges surrounding Data Sharing from the Perspective of Research Funding Agencies – A Qualitative Expert Interview Study [Interview Excerpts]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'This dataset contains summaries from interviews with data sharing experts from internationa funding agencies on their organisation's data sharing policy.Data Sharing is widely recognised as crucial for accelerating scientific research and improving its quality. However, data sharing is still not a common practice. Funding agencies tend to facilitate the sharing of research data by both providing incentives and requiring data sharing as part of their policies and conditions for awarding grants. The goal of our article is to answer the following question: What challenges do international funding agencies see when it comes to their own efforts to foster and implement data sharing through their policies?We conducted a series of sixteen guideline-based expert interviews with representatives of leading international funding agencies. As contact persons for open science at their respective agencies, they offered their perspectives and experiences concerning their organisations’ data sharing policies. We performed a qualitative content analysis of the interviews and categorised the challenges perceived by funding agencies.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Data Management; Data Sharing; Data Sharing Policies; FAIR Data; Interview study; Qualitative content analysis; Research funders; Research funding agencies'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Neither Carrots nor Sticks? Challenges surrounding Data Sharing from the Perspective of Research Funding Agencies – A Qualitative Expert Interview Study [Interview Excerpts]' Description:'This dataset contains summaries from interviews with data sharing experts from internationa funding agencies on their organisation's data sharing policy.Data Sharing is widely recognised as crucial for accelerating scientific research and improving its quality. However, data sharing is still not a common practice. Funding agencies tend to facilitate the sharing of research data by both providing incentives and requiring data sharing as part of their policies and conditions for awarding grants. The goal of our article is to answer the following question: What challenges do international funding agencies see when it comes to their own efforts to foster and implement data sharing through their policies?We conducted a series of sixteen guideline-based expert interviews with representatives of leading international funding agencies. As contact persons for open science at their respective agencies, they offered their perspectives and experiences concerning their organisations’ data sharing policies. We performed a qualitative content analysis of the interviews and categorised the challenges perceived by funding agencies.' Subject:'Medicine, Health and Life Sciences; Social Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
This dataset contains summaries from interviews with data sharing experts from internationa funding agencies on their organisation's data sharing policy.Data Sharing is widely recognised as crucial for accelerating scientific research and improving its quality. However, data sharing is still not a common practice. Funding agencies tend to facilitate the sharing of research data by both providing incentives and requiring data sharing as part of their policies and conditions for awarding grants. The goal of our article is to answer the following question: What challenges do international funding agencies see when it comes to their own efforts to foster and implement data sharing through their policies?We conducted a series of sixteen guideline-based expert interviews with representatives of leading international funding agencies. As contact persons for open science at their respective agencies, they offered their perspectives and experiences concerning their organisations’ data sharing policies. We performed a qualitative content analysis of the interviews and categorised the challenges perceived by funding agencies.
|
Social Sciences
|
Data Management; Data Sharing; Data Sharing Policies; FAIR Data; Interview study; Qualitative content analysis; Research funders; Research funding agencies
|
doi:10.11588/data/M5ZUPP
|
Translation initiation factor eIF3m controls ubiquitination-dependent early elongation pausing of ribosomes
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'While translation initiation is extensively regulated, fewer mechanisms are known to control translation elongation. We discovered that prolonged stimulation of macrophages leads to suppression of protein synthesis at the level of translation elongation, through pausing of ribosomes on the first 20 codons of mRNA open reading frames. Early elongation pausing results from ubiquitination of the translation machinery including the translation initiation factor eIF3m. We demonstrate that eIF3m is required for efficient early elongation in unstimulated macrophages. The mechanism is of general nature, since eIF3m and ubiquitination control early elongation pausing also in cells outside of the immune system. This work uncovers early elongation as a critical phase during which polypeptide synthesis is actively controlled.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'macrophage activation; mass spectrometry; ubiquitinome analysis'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Translation initiation factor eIF3m controls ubiquitination-dependent early elongation pausing of ribosomes' Description:'While translation initiation is extensively regulated, fewer mechanisms are known to control translation elongation. We discovered that prolonged stimulation of macrophages leads to suppression of protein synthesis at the level of translation elongation, through pausing of ribosomes on the first 20 codons of mRNA open reading frames. Early elongation pausing results from ubiquitination of the translation machinery including the translation initiation factor eIF3m. We demonstrate that eIF3m is required for efficient early elongation in unstimulated macrophages. The mechanism is of general nature, since eIF3m and ubiquitination control early elongation pausing also in cells outside of the immune system. This work uncovers early elongation as a critical phase during which polypeptide synthesis is actively controlled.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
While translation initiation is extensively regulated, fewer mechanisms are known to control translation elongation. We discovered that prolonged stimulation of macrophages leads to suppression of protein synthesis at the level of translation elongation, through pausing of ribosomes on the first 20 codons of mRNA open reading frames. Early elongation pausing results from ubiquitination of the translation machinery including the translation initiation factor eIF3m. We demonstrate that eIF3m is required for efficient early elongation in unstimulated macrophages. The mechanism is of general nature, since eIF3m and ubiquitination control early elongation pausing also in cells outside of the immune system. This work uncovers early elongation as a critical phase during which polypeptide synthesis is actively controlled.
|
Medicine, Health and Life Sciences
|
macrophage activation; mass spectrometry; ubiquitinome analysis
|
doi:10.11588/data/MYFILV
|
Structural integration of personality mediates the effects of adverse and protective childhood experiences on the course of psychotherapy [Results]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Analysis of the psychotherapy data from the HIP (Heidelberger Institute for Psychotherapy).We checked whether the speed of patients' symptom improvement depended on their childhood experiences. We used the structural integration of personality as mediating factors.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'ACE; Childhood Experiences; PCE; Psychotherapy Research'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Structural integration of personality mediates the effects of adverse and protective childhood experiences on the course of psychotherapy [Results]' Description:'Analysis of the psychotherapy data from the HIP (Heidelberger Institute for Psychotherapy).We checked whether the speed of patients' symptom improvement depended on their childhood experiences. We used the structural integration of personality as mediating factors.' Subject:'Medicine, Health and Life Sciences; Other; Social Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Analysis of the psychotherapy data from the HIP (Heidelberger Institute for Psychotherapy).We checked whether the speed of patients' symptom improvement depended on their childhood experiences. We used the structural integration of personality as mediating factors.
|
Medicine, Health and Life Sciences
|
ACE; Childhood Experiences; PCE; Psychotherapy Research
|
doi:10.11588/data/MYFILV
|
Structural integration of personality mediates the effects of adverse and protective childhood experiences on the course of psychotherapy [Results]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Analysis of the psychotherapy data from the HIP (Heidelberger Institute for Psychotherapy).We checked whether the speed of patients' symptom improvement depended on their childhood experiences. We used the structural integration of personality as mediating factors.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'ACE; Childhood Experiences; PCE; Psychotherapy Research'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Structural integration of personality mediates the effects of adverse and protective childhood experiences on the course of psychotherapy [Results]' Description:'Analysis of the psychotherapy data from the HIP (Heidelberger Institute for Psychotherapy).We checked whether the speed of patients' symptom improvement depended on their childhood experiences. We used the structural integration of personality as mediating factors.' Subject:'Medicine, Health and Life Sciences; Other; Social Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Analysis of the psychotherapy data from the HIP (Heidelberger Institute for Psychotherapy).We checked whether the speed of patients' symptom improvement depended on their childhood experiences. We used the structural integration of personality as mediating factors.
|
Other
|
ACE; Childhood Experiences; PCE; Psychotherapy Research
|
doi:10.11588/data/MYFILV
|
Structural integration of personality mediates the effects of adverse and protective childhood experiences on the course of psychotherapy [Results]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Analysis of the psychotherapy data from the HIP (Heidelberger Institute for Psychotherapy).We checked whether the speed of patients' symptom improvement depended on their childhood experiences. We used the structural integration of personality as mediating factors.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'ACE; Childhood Experiences; PCE; Psychotherapy Research'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Structural integration of personality mediates the effects of adverse and protective childhood experiences on the course of psychotherapy [Results]' Description:'Analysis of the psychotherapy data from the HIP (Heidelberger Institute for Psychotherapy).We checked whether the speed of patients' symptom improvement depended on their childhood experiences. We used the structural integration of personality as mediating factors.' Subject:'Medicine, Health and Life Sciences; Other; Social Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Analysis of the psychotherapy data from the HIP (Heidelberger Institute for Psychotherapy).We checked whether the speed of patients' symptom improvement depended on their childhood experiences. We used the structural integration of personality as mediating factors.
|
Social Sciences
|
ACE; Childhood Experiences; PCE; Psychotherapy Research
|
doi:10.11588/data/NULJJR
|
Comparison of perfusion models for quantitative T1 weighted DCE-MRI of rectal cancer [Dataset]
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Twenty-six patients with newly diagnosed rectal carcinoma underwent 3T MRI of the pelvis including a T1 weighted dynamic contrast enhanced (DCE) protocol before treatment. For eighteen patients, mean values for Plasma Flow (PF), Plasma Volume (PV) and Mean Transit Time (MTT) were obtained for three perfusion models.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'Dynamic contrast-enhanced MRI (DCE MRI); Pharmacokinetic modelling; Rectal cancer'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Comparison of perfusion models for quantitative T1 weighted DCE-MRI of rectal cancer [Dataset]' Description:'Twenty-six patients with newly diagnosed rectal carcinoma underwent 3T MRI of the pelvis including a T1 weighted dynamic contrast enhanced (DCE) protocol before treatment. For eighteen patients, mean values for Plasma Flow (PF), Plasma Volume (PV) and Mean Transit Time (MTT) were obtained for three perfusion models.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Twenty-six patients with newly diagnosed rectal carcinoma underwent 3T MRI of the pelvis including a T1 weighted dynamic contrast enhanced (DCE) protocol before treatment. For eighteen patients, mean values for Plasma Flow (PF), Plasma Volume (PV) and Mean Transit Time (MTT) were obtained for three perfusion models.
|
Medicine, Health and Life Sciences
|
Dynamic contrast-enhanced MRI (DCE MRI); Pharmacokinetic modelling; Rectal cancer
|
doi:10.11588/data/NWE2JJ
|
Histopathology of thymectomy specimens from the MGTX-trial
|
<|begin_of_text|><|start_header_id|>system<|end_header_id|> You are a research archivist expert in dataset metadata. Answer the question truthfully. <|eot_id|><|start_header_id|>user<|end_header_id|> Here is the Description of a dataset. Description:'Background:The thymectomy specimens from the “thymectomy trial in non-thymomatous myasthenia gravis patients receiving prednisone therapy” (MGTX) [1] underwent rigid and comprehensive work-up, which results in a unique, spatially mapped dataset. Fig. 1 Specimen work-up:Work-up scheme for the specimens in the MGTX trial [1, 2]. Thymuses were sub-divided into regions that underwent predefined evaluation (e.g. complete work-up of the central A-region, partial work-up of other regions) Content:A xlsx-file with one table for patient data (“dataPatients” with age, gender etc.), one table with histomorphological data for the specimen regions (“dataAllRegions” with grading atrophy, grading overall fat etc.) and one table for the follicle morphology in the A region (“dataARegion” with n follicle with germinal centre etc.). References:1.Wolfe, G.I., et al., Randomized Trial of Thymectomy in Myasthenia Gravis. N Engl J Med, 2016. 375(6): p. 511-22. 2.Ströbel, P., et al., The ageing and myasthenic thymus: A morphometric study validating a standard procedure in the histological workup of thymic specimens. Journal of Neuroimmunology, 2008. 201–202: p. 64-73.' . Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:.<|eot_id|><|start_header_id|>assistant<|end_header_id|> Answer : {'MGTX'} <|eot_id|>
|
Here are Title, Description and Subject of a dataset. Title :'Histopathology of thymectomy specimens from the MGTX-trial' Description:'Background:The thymectomy specimens from the “thymectomy trial in non-thymomatous myasthenia gravis patients receiving prednisone therapy” (MGTX) [1] underwent rigid and comprehensive work-up, which results in a unique, spatially mapped dataset. Fig. 1 Specimen work-up:Work-up scheme for the specimens in the MGTX trial [1, 2]. Thymuses were sub-divided into regions that underwent predefined evaluation (e.g. complete work-up of the central A-region, partial work-up of other regions) Content:A xlsx-file with one table for patient data (“dataPatients” with age, gender etc.), one table with histomorphological data for the specimen regions (“dataAllRegions” with grading atrophy, grading overall fat etc.) and one table for the follicle morphology in the A region (“dataARegion” with n follicle with germinal centre etc.). References:1.Wolfe, G.I., et al., Randomized Trial of Thymectomy in Myasthenia Gravis. N Engl J Med, 2016. 375(6): p. 511-22. 2.Ströbel, P., et al., The ageing and myasthenic thymus: A morphometric study validating a standard procedure in the histological workup of thymic specimens. Journal of Neuroimmunology, 2008. 201–202: p. 64-73.' Subject:'Medicine, Health and Life Sciences. Please return only a json list of at most 3 Keywords corresponding to the Title, Description and Subject:
|
Background:The thymectomy specimens from the “thymectomy trial in non-thymomatous myasthenia gravis patients receiving prednisone therapy” (MGTX) [1] underwent rigid and comprehensive work-up, which results in a unique, spatially mapped dataset. Fig. 1 Specimen work-up:Work-up scheme for the specimens in the MGTX trial [1, 2]. Thymuses were sub-divided into regions that underwent predefined evaluation (e.g. complete work-up of the central A-region, partial work-up of other regions) Content:A xlsx-file with one table for patient data (“dataPatients” with age, gender etc.), one table with histomorphological data for the specimen regions (“dataAllRegions” with grading atrophy, grading overall fat etc.) and one table for the follicle morphology in the A region (“dataARegion” with n follicle with germinal centre etc.). References:1.Wolfe, G.I., et al., Randomized Trial of Thymectomy in Myasthenia Gravis. N Engl J Med, 2016. 375(6): p. 511-22. 2.Ströbel, P., et al., The ageing and myasthenic thymus: A morphometric study validating a standard procedure in the histological workup of thymic specimens. Journal of Neuroimmunology, 2008. 201–202: p. 64-73.
|
Medicine, Health and Life Sciences
|
MGTX
|
End of preview. Expand
in Data Studio
No dataset card yet
- Downloads last month
- 4